Generic Name: levoleucovorin (LEE voe LOO koe voe rin)
Brand Name: Fusilev
What is Fusilev (levoleucovorin)?
Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.
Levoleucovorin is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized. Levoleucovorin may also be used to treat toxic effects of an accidental methotrexate overdose.
Levoleucovorin is also used in combination chemotherapy with fluorouracil to treat colorectal cancer that has spread to other parts of the body. Levoleucovorin treats only the symptoms of colorectal cancer but does not treat the cancer itself.
Levoleucovorin should not be used to treat anemia that is caused by a lack of vitamin B12.
Levoleucovorin may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Fusilev (levoleucovorin)?
You should not receive this medication if you are allergic to levoleucovorin or to folic acid or folinic acid.
What should I discuss with my healthcare provider before I receive Fusilev (levoleucovorin)?
You should not receive this medicine if you are allergic to levoleucovorin, folic acid, or folinic acid.
If possible, before you receive levoleucovorin, tell your doctor or caregivers if you have:
liver disease; or
if you are dehydrated.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether levoleucovorin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using levoleucovorin.
In an emergency situation, it may not be possible before you are treated with levoleucovorin to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.
How is Fusilev (levoleucovorin)given?
Levoleucovorin is injected into a vein through an IV. A healthcare provider will give you this injection.
For methotrexate toxicity, levoleucovorin is usually given every 6 hours for 10 doses. You will most likely receive your first dose 24 hours after the start of your methotrexate infusion, or as soon as possible within the first 24 hours after accidental overdose.
For colorectal cancer levoleucovorin is usually given daily as a 5-day treatment, repeated every 4 to 5 weeks.
After treatment with levoleucovorin, you will be watched to make sure this medicine has been effective and you no longer have any effects of methotrexate.
You will need frequent medical tests to help your doctor determine how long to treat you with levoleucovorin.
What happens if I miss a dose?
If this medication is given by a healthcare professional in an clinical setting, you are not likely to miss a dose.
If you are receiving levoleucovorin daily in 4-week treatment cycles, call your doctor for instructions if you miss an appointment for your scheduled injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving Fusilev (levoleucovorin)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Fusilev (levoleucovorin) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor or caregivers at once if you have:
blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
severe ongoing nausea, vomiting, or diarrhea;
a light-headed feeling, like you might pass out;
dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or
kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Fusilev (levoleucovorin)?
Tell your doctor about all your current medicines and any you start or stop using, especially:
a multivitamin or mineral supplement than contains folic acid; or
a sulfa drug (Bactrim, Septra, Sulfatrim, SMX-TMP or SMZ-TMP, and others).
This list is not complete. Other drugs may interact with levoleucovorin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Fusilev (levoleucovorin calcium)
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about levoleucovorin.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 3.03.
Date modified: October 14, 2016
Last reviewed: September 15, 2015