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Generic name: cevimelinese-vi-ME-leen ]
Drug class: Cholinergic agonists

Medically reviewed by on Jul 26, 2023. Written by Cerner Multum.

What is Evoxac?

Evoxac increases the secretions of the saliva and sweat glands in the body.

Evoxac is used to treat dry mouth in people with Sjögren's Syndrome.

Evoxac may also be used for purposes not listed in this medication guide.

Evoxac side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Evoxac may cause serious side effects. Stop using Evoxac and call your doctor at once if you have:

  • severe pain in your stomach, side, or lower back;

  • vomiting;

  • fast, slow, or uneven heart rate;

  • painful or difficult urination;

  • a light-headed feeling, like you might pass out; or

  • dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Common side effects of Evoxac may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not take Evoxac if you have uncontrolled asthma, glaucoma, or an eye condition called iritis or uveitis.

What should I tell my healthcare provider before taking Evoxac?

You should not take Evoxac if you are allergic to it, or if you have:

  • untreated or uncontrolled asthma;

  • narrow-angle glaucoma; or

  • an eye condition called iritis or uveitis.

To make sure Evoxac is safe for you, tell your doctor if you have:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether cevimeline passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Evoxac is not approved for use by anyone younger than 18 years old.

How should I take Evoxac?

Follow all directions on your prescription label. Do not take Evoxac in larger or smaller amounts or for longer than recommended.

Drink plenty of liquids while you are taking Evoxac. This will help keep your kidneys working properly, and can also prevent dehydration.

Evoxac is usually taken 3 times per day. Follow your doctor's dosing instructions.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, vision problems, confusion, sweating, tremors, vomiting, diarrhea, feeling short of breath, and irregular heartbeats.

What should I avoid while taking Evoxac?

Evoxac may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Evoxac can decrease sweating and you may be more prone to heat stroke.

What other drugs will affect Evoxac?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • an antibiotic or antifungal medicine;

  • an antidepressant;

  • antiviral medicine to treat hepatitis C or HIV/AIDS; or

  • heart or blood pressure medication.

This list is not complete. Other drugs may interact with cevimeline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.