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Evoxac Side Effects

Generic name: cevimeline

Medically reviewed by Drugs.com. Last updated on Sep 5, 2024.

Note: This document provides detailed information about Evoxac.

Applies to cevimeline: oral capsule Side Effects associated with cevimeline. Some dosage forms listed on this page may not apply specifically to the brand name Evoxac.

Applies to cevimeline: oral capsule.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

This medicine may worsen the condition of patients with heart disease or heart rhythm problems. Check with your doctor right away if you have chest pain or tightness, decreased urine output, dilated neck veins, extreme fatigue, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, troubled breathing, or weight gain. You might also feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat.

Tell your doctor right away if you have a cough, trouble breathing, chest tightness, or any type of breathing problem with this medicine. These could be symptoms of a serious lung problem.

This medicine may cause blurred or decreased vision, especially at night and in patients with eye problems. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

This medicine may cause kidney or gallbladder problems. Check with your doctor right away if you have severe nausea or vomiting, indigestion, stomach pain, itchy skin, light-colored stools, yellow eyes or skin, bloody or cloudy urine, or pain in the lower back or side.

Drink plenty of water, especially if you have excessive sweating, to prevent dehydration.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cevimeline (the active ingredient contained in Evoxac)

Check with your doctor immediately if any of the following side effects occur while taking cevimeline:

More common side effects

  • bladder pain
  • bloody or cloudy urine
  • body aches or pain
  • chills
  • cough
  • difficult, burning, or painful urination
  • difficulty in breathing
  • dryness or soreness of the throat
  • ear congestion
  • frequent urge to urinate
  • headache
  • hoarseness
  • loss of voice
  • lower back or side pain
  • runny or stuffy nose
  • sneezing
  • tender, swollen glands in the neck
  • trouble in swallowing
  • unusual tiredness or weakness
  • voice changes

Less common side effects

  • accumulation of pus
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision or other change in vision
  • burning, dry, or itching eyes
  • chest pain
  • cough producing mucus
  • diarrhea
  • discharge, excessive tearing
  • dizziness
  • earache
  • excessive muscle tone
  • eye pain
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling unusually cold
  • fever
  • general feeling of discomfort or illness
  • headache, severe and throbbing
  • heartburn
  • hives, skin rash
  • joint pain
  • loss of appetite
  • muscle pain, stiffness, tension, or tightness
  • nausea
  • nosebleed
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • redness or swelling in the ear
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • sensitivity of the eye to light
  • shivering
  • sore throat
  • swollen, red, tender area of the infection site
  • tightness in the chest
  • tingling of the hands or feet
  • tremor
  • trouble sleeping
  • unusual bleeding or bruising
  • unusual weight gain or loss
  • vomiting
  • weight loss

Rare side effects

  • anxiety
  • black, tarry stools
  • bleeding after defecation
  • bleeding gums
  • blisters
  • bloating
  • blood in the urine or stools
  • blood in vomit
  • bloody nose
  • blue or pale skin
  • burning feeling in the chest or stomach
  • burning feeling while urinating
  • burning, numbness, pain, or tingling in all fingers, except the smallest finger
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • changes in skin color
  • chest discomfort
  • chest pain, possibly moving to the left arm, neck, or shoulder
  • choking
  • clumsiness or unsteadiness
  • cold sweats
  • collection of blood under the skin
  • confusion
  • constipation
  • cool, pale skin
  • coughing or spitting up blood
  • cracked lips
  • decreased urination
  • deep, dark purple bruise
  • depressed mood
  • difficulty controlling your bladder or bowels
  • difficulty walking
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • dry skin and hair
  • dry, puffy skin
  • extra heartbeat
  • fainting
  • feeling cold
  • forgetfulness
  • frequent urge to defecate
  • fruit-like breath odor
  • gaseous abdominal pain
  • heart murmur
  • heavier menstrual periods
  • husky voice
  • incoherent speech
  • increase in heart rate
  • increased hunger
  • increased thirst
  • increased volume of pale, dilute urine
  • indigestion
  • involuntary muscle contractions
  • irregular heartbeat
  • irritation or soreness of the mouth
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • joint stiffness or swelling
  • lightheadedness
  • loss of bladder control
  • loss of consciousness
  • lower back, side, or stomach pain
  • metallic taste
  • mood changes
  • muscle cramps or weakness
  • nerve pain
  • nervousness
  • nightmares
  • noisy breathing
  • numbness or tingling in the face, hands, feet, or lips
  • pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion
  • pain or burning in the throat
  • pain or discomfort in the arms, jaw, back, or neck pain, warmth, or burning in the fingers, toes, and legs
  • painful blisters on the trunk of the body
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • pale, bluish-colored, or cold hands or feet
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid, shallow breathing
  • rectal bleeding
  • recurrent fever
  • redness and swelling of the gums
  • redness, soreness, or itching skin
  • redness, swelling, or soreness of the tongue
  • seizures
  • sensation of pins and needles
  • severe constipation
  • severe cramping
  • severe or continuing stomach pain
  • severe stomach pain
  • severe vomiting
  • shakiness
  • slow heartbeat
  • slurred speech
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • stabbing pain
  • stomach bloating, burning, cramping, or pain
  • stomach tenderness or discomfort
  • stomach upset or fullness
  • straining while passing stool
  • sudden decrease in the amount of urine
  • sunken eyes
  • sweating
  • swelling around the eyes
  • swelling of the front part of the neck
  • swelling or inflammation of the mouth
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble in holding urine
  • uncomfortable swelling around the anus
  • unexplained weight loss
  • voice changes
  • vomiting of blood or material that looks like coffee grounds
  • weak or absent pulses in the legs
  • weight gain
  • wrinkled skin
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking cevimeline:

Symptoms of Overdose

Other side effects of Evoxac

Some side effects of cevimeline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • back pain
  • belching
  • bloated, full feeling
  • bone pain
  • change in the color, amount, or odor of vaginal discharge
  • difficulty in moving
  • discouragement
  • excess air or gas in stomach or bowels
  • feeling of constant movement of self or surroundings
  • feeling of warmth feeling sad or empty
  • hiccup
  • increased watering of the mouth
  • irritability
  • itching of the vagina or genital area
  • leg cramps
  • loss of interest or pleasure
  • overactive reflexes, followed by underactive reflexes
  • pain during sexual intercourse
  • passing gas
  • redness of the face, neck, arms, and occasionally, upper chest
  • salivary gland enlargement or pain
  • sensation of spinning
  • thick, white vaginal discharge with no odor or with a mild odor
  • tooth disorder
  • toothache
  • trouble concentrating

Rare side effects

  • abnormal crying
  • abnormal dreaming
  • absence of menstruation
  • acne
  • agitation
  • change in tongue color
  • changes in menstrual periods
  • decreased sexual ability in males
  • difficulty in speaking
  • discoloration of the fingernails or toenails
  • false beliefs that cannot be changed by facts
  • feeling of unreality
  • hair loss or thinning of hair
  • increase in body movements
  • increased appetite
  • increased sensitivity of skin to sunlight
  • lack or loss of strength
  • painful menstruation
  • poor insight and judgment
  • problems with memory or speech
  • seeing, hearing, or feeling things that are not there
  • sense of detachment from self or body
  • severe sunburn
  • sleepiness or unusual drowsiness
  • trouble recognizing objects
  • trouble thinking and planning
  • trouble walking

For healthcare professionals

Applies to cevimeline: oral capsule.

General adverse events

The most commonly reported side effects were excessive sweating, nausea, diarrhea, rhinitis, sinusitis, upper respiratory tract infection, and headache.[Ref]

Cardiovascular

Hepatic

Hematologic

Gastrointestinal

Nervous system

Respiratory

Genitourinary

Musculoskeletal

Dermatologic

Ocular

Endocrine

Immunologic

Metabolic

Oncologic

Other

Psychiatric

Renal

See also:

References

1. (2001) "Product Information. Evoxac (cevimeline)." Daiichi Pharmaceuticals

Further information

Evoxac side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.