Avelumab
Generic name: avelumab [ a-VEL-ue-mab ]
Brand name: Bavencio
Dosage form: intravenous solution (20 mg/mL)
Drug class: Anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)
What is avelumab?
Avelumab is used to treat a type of skin cancer called Merkel cell carcinoma in adults and children at least 12 years old, when the cancer has spread to other parts of the body (metastatic).
Avelumab is also used to treat a certain type of cancer of the bladder or urinary tract that has spread or cannot be removed with surgery. Avelumab is given for this condition after platinum cancer medicines did not work or have stopped working.
Avelumab is also used alone or in combination with another medicine called axitinib to treat advanced kidney cancer that has spread or cannot be removed with surgery.
Avelumab may also be used for purposes not listed in this medication guide.
Avelumab side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver right away if you feel light-headed, itchy, feverish, chilled, or have stomach or back pain, trouble breathing, or flushing (warmth, redness, or tingly feeling).
Avelumab works by causing your immune system to attack tumor cells. Avelumab may cause your immune system to attack healthy organs and tissues in your body. This could lead to serious or life-threatening side effects on your lungs, liver, pancreas, kidneys, intestines, thyroid, or adrenal glands.
Avelumab may cause serious side effects. Call your doctor at once if you have:
-
sudden chest pain or discomfort;
-
severe stomach pain, diarrhea, bloody or tarry stools;
-
blistering or peeling skin rash;
-
pounding heartbeats or fluttering in your chest;
-
flu-like symptoms;
-
pain or burning when you urinate;
-
joint pain, weakness;
-
vision changes;
-
liver problems--loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
-
heart problems--chest pain or pressure, pain spreading to your jaw or shoulder, sweating;
-
kidney problems--little or no urination, red or pink urine, swelling in your feet or ankles; or
-
signs of a hormonal disorder--feeling light-headed or very tired, rapid heartbeats, mood or behavior changes, deepened voice, increased hunger or thirst, increased urination, constipation, vomiting, hair loss, sweating, feeling cold, weight gain, or weight loss.
Common side effects of avelumab may include:
-
hoarse voice;
-
cough, shortness of breath;
-
trouble speaking;
-
pain, blisters, bleeding, or severe rash on the palms of your hands or the soles of your feet;
-
sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;
-
severe headache, blurred vision, pounding in your neck or ears;
-
painful urination;
-
stomach pain, nausea, diarrhea, loss of appetite;
-
feeling tired;
-
chills, fever;
-
muscle pain, back pain, bone pain;
-
rash;
-
swelling in your hands or feet;
-
redness or swelling where the injection was given;
-
liver problems; or
-
symptoms of underactive thyroid--tiredness, depressed mood, dry skin, thinning hair, decreased sweating, weight gain, puffiness in your face, feeling more sensitive to cold temperatures.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Related/similar drugs
Keytruda
Keytruda is used to treat multiple types of cancer such as melanoma, non-small cell lung cancer ...
Avastin
Avastin is used to brain tumors and cancers of the kidney, colon, rectum, or lung. Learn about side ...
Otezla
Otezla (apremilast) is used to treat plaque psoriasis, psoriatic arthritis, and oral ulcers ...
Lenvima
Lenvima (lenvatinib) is used to treat thyroid cancer, advanced renal cell carcinoma, hepatocellular ...
Opdivo
Opdivo is used to treat many cancers, such as melanoma, non-small cell lung cancer, malignant ...
Cabometyx
Cabometyx is used to treat advanced kidney cancer, liver cancer, thyroid cancer, and pancreatic and ...
Cabozantinib
Cabozantinib systemic is used for hepatocellular carcinoma, neuroendocrine tumors, renal cell ...
Everolimus
Everolimus (Afinitor, Afinitor Disperz, Zortress) belongs to a class of drugs called kinase ...
Nivolumab
Nivolumab (brand name Opdivo) is an immunotherapy treatment that treats many cancers, such as ...
Bevacizumab
Bevacizumab injection is a targeted cancer drug used to treat types of non-small cell lung cancer ...
Warnings
Avelumab works by causing your immune system to attack tumor cells. Avelumab may cause your immune system to attack healthy organs and tissues in your body. This could lead to serious or life-threatening side effects on your lungs, liver, pancreas, kidneys, intestines, thyroid, or adrenal glands.
Call your doctor at once if you have symptoms such as: fever, cough, flu symptoms, muscle pain or weakness, vision changes, chest pain, trouble breathing, severe stomach pain or diarrhea, skin rash, swelling in your ankles, increased or decreased urination, blood in your urine or stools, weight changes, hair loss, unusual bleeding, dark urine, or jaundice (yellowing of your skin or eyes).
Before taking this medicine
Tell your doctor if you have ever had:
-
a condition that affects your nervous system such as myasthenia gravis or Guillain-Barré syndrome;
-
an immune system disorder such as ulcerative colitis or Crohn's disease;
-
lung problems or a breathing disorder;
-
liver or kidney disease;
-
heart problems or high blood pressure;
-
diabetes;
-
an organ transplant; or
-
if you have received or will receive a transplant of stem cells from a donor.
You should not use avelumab if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using avelumab and for at least 1 month after your last dose.
You should not breastfeed while using this medicine and for at least 1 month after your last dose.
How is avelumab given?
Avelumab is given as an infusion into a vein, usually once every 2 weeks. A healthcare provider will give you this injection.
Avelumab must be given slowly and the IV infusion can take at least 60 minutes to complete.
You may be given other medication to prevent certain side effects that may occur during the infusion.
You may need frequent medical tests to check your heart or liver function, and to help your doctor determine how long to treat you with avelumab.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your avelumab injection.
What happens if I overdose?
Since avelumab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving avelumab?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
What other drugs will affect avelumab?
Other drugs may affect avelumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Avelumab Biosimilars
Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.
Reference products
These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for avelumab.
Bavencio (avelumab) - EMD Serono, Inc.
Formulation type | Strength |
---|---|
Single-Dose Vial | 200 mg/10 mL (20 mg/mL) |
View Bavencio information in detail.
Popular FAQ
Who makes Bavencio and where is it made?
Bavencio is made by EMD Serono, Inc., a pharmaceutical company located in Rockland, Massachusetts, USA. You can contact EMD Serono by calling +1-800-283-8088 or contact them online. Continue reading
What type of drug is Bavencio?
Bavencio (avelumab) is a programmed death ligand-1 (PD-L1) blocking antibody. Bavencio targets the PD-L1 receptors, which are protein receptors on cell surfaces. When Bavencio blocks PD-L1, it 'turns on' the ability of cancer-fighting cells such as T-cells to attack and kill tumors. Continue reading
More about avelumab
- Check interactions
- Compare alternatives
- Reviews (1)
- Side effects
- Dosage information
- During pregnancy
- Drug class: anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2025 Cerner Multum, Inc. Version: 5.01.