What is aducanumab?
Aducanumab is used to treat people with Alzheimer's disease.
Aducanumab may also be used for purposes not listed in this medication guide.
Aducanumab can cause temporary swelling or bleeding in the brain that usually clears up with time. This may cause no symptoms but can be serious. Call your doctor if you have headaches, dizziness, nausea, confusion, or vision changes.
Before taking this medicine
Aducanumab can cause a condition called Amyloid Related Imaging Abnormalities or "ARIA."
ARIA is a temporary swelling or small spots of bleeding in the brain that usually clears up with time. Your doctor may perform an MRI of your brain before you receive aducanumab.
Tell your doctor if you are pregnant or breastfeeding.
How is aducanumab given?
Aducanumab is injected into a vein by a healthcare provider.
This medicine is injected slowly over 1 hour.
Aducanumab is usually given every 4 weeks, at least 21 days apart.
You will need occasional brain MRIs while receiving aducanumab.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose.
What happens if I overdose?
In a medical setting an overdose would be treated quickly.
What should I avoid while receiving aducanumab?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Aducanumab side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your care provider if you have a rash, trouble breathing, or swelling in your face.
Aducanumab can cause temporary swelling or bleeding in the brain. Call your doctor if you have:
Common side effects of aducanumab may include:
ARIA with symptoms, or with signs that appear on an MRI;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Aducanumab dosing information
Usual Adult Dose for Alzheimer's Disease:
Titration is required for treatment initiation: Doses are infused over 1 hour every 4 weeks:
-Infusion 1 and 2: 1 mg/kg IV
-Infusion 3 and 4: 3 mg/kg IV
-Infusion 5 and 6: 6 mg/kg IV
Maintenance dose: 10 mg/kg IV once every 4 weeks
-Administer via IV infusion approximately every 4 weeks and at least 21 days apart.
-Study patients in the clinical trials had mild cognitive impairment or mild dementia stage of disease; there are no safety or
effectiveness data on initiating treatment at earlier or later stages of the disease than were studied.
-This drug has been approved under an accelerated approval based on reduction in amyloid beta plaques observed in patients treated in clinical studies; continued approval may be contingent upon verification of clinical benefit in confirmatory trials.
Use: For the treatment of Alzheimer's disease in patients with mild cognitive impairment or mild dementia stage of disease.
What other drugs will affect aducanumab?
Where can I get more information?
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
More about aducanumab
- Check interactions
- Side effects
- Dosage information
- During pregnancy
- Drug class: miscellaneous central nervous system agents
- En español
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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