Rilonacept
Brand name: Arcalyst
Drug class: Other Miscellaneous Therapeutic Agents
- Interleukin-1 Receptor Antagonists
- Interleukin-1 Inhibitors
Chemical name: Interleukin 1 receptor accessory protein (human extracellular domain fragment) fusion protein with type I interleukin 1 receptor (human extracellular domain fragment) fusion protein with immunoglobulin G1 (human Fc fragment), homodimer
Molecular formula: C9030H13932N2400O2670S74
CAS number: 501081-76-1
Introduction
Interleukin-1 (IL-1) receptor antagonist (IL-1Ra); dimeric fusion protein.
Uses for Rilonacept
Cryopyrin-associated Periodic Syndromes
Long-term management of cryopyrin-associated periodic syndromes (CAPS), including familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS), in adults and children ≥12 years of age; designated an orphan drug by FDA for use in these conditions.
Results in improvements in each of 5 components of a composite symptom score (joint pain, rash, fever or chills, eye redness or pain, and fatigue). Also results in decreases in mean concentrations of acute phase reactants (serum amyloid A [SAA] and C-reactive protein [CRP]).
Rilonacept Dosage and Administration
Administration
Sub-Q Administration
Administer by sub-Q injection only; do not give by IM, IV, or intra-arterial injection.
Perform the first injection of rilonacept under the supervision of a clinician; subsequent injections may be self-administered if the clinician determines that the patient and/or their caregiver is competent to safely administer the drug after appropriate training and with medical follow-up as necessary.
Inject sub-Q into the upper arms, thighs, or abdomen (avoid the 2-inch area around the navel); rotate injection sites to prevent irritation and to allow complete absorption of the drug.
Injection sites in the abdomen and thigh are preferred if the patient is administering the drug; if another person is administering the injection, may use the upper arm. Do not inject into areas where the skin is bruised, red, swollen, tender, or hard.
Gently pinch tissue around the injection site and insert needle at a 90° angle (45° angle may be appropriate for small children and thin individuals). After pulling back the plunger to ensure that blood is not aspirated, inject drug at a slow, steady rate; up to 30 seconds may be required to inject the entire dose.
Divide doses exceeding 160 mg (2 mL) equally into 2 syringes and inject on the same day into 2 separate sites.
Reconstitution
Reconstitute the appropriate number of vials of the drug based on the indicated dosage of rilonacept.
Prior to administration, reconstitute rilonacept lyophilized powder for injection using proper aseptic technique by adding 2.3 mL of preservative-free sterile water for injection (using a 3-mL syringe with a 27-gauge, ½-inch needle) to a vial labeled as containing 220 mg of rilonacept to provide a solution containing 80 mg/mL.
Hold the vial sideways (not upright) and shake back and forth (side-to-side) for approximately one minute, then allow to sit for one minute. If the powder is not completely dissolved, shake the vial for approximately 30 seconds more and then allow to sit for one minute; repeat the process until the powder is completely dissolved and the solution is clear. The reconstituted solution should be viscous, clear, colorless to pale yellow, and essentially free from particulates.
Discard the needle and syringe used for reconstitution; do not use for sub-Q injection.
Before administration, withdraw the appropriate dose of rilonacept (up to 160 mg or 2 mL) into a new 3-mL syringe using a new 27-gauge, ½-inch needle. Discard unused portions of the reconstituted solution since the solution contains no preservatives.
Dosage
Pediatric Patients
Cryopyrin-associated Periodic Syndromes
Sub-Q
Usual loading dose in children 12–17 years of age: 4.4 mg/kg (up to 320 mg) given as 1 or 2 injections (maximum 160 mg [2 mL] per injection).
Usual maintenance dosage in children 12–17 years of age: 2.2 mg/kg (up to 160 mg) given as a single injection once weekly beginning 1 week after the loading dose.
Safety and efficacy of lower doses or longer dosing intervals not established.
Adults
Cryopyrin-associated Periodic Syndromes
Sub-Q
Usual loading dose: 320 mg given as 2 divided injections of 160 mg each.
Usual maintenance dosage: 160 mg given as a single injection once weekly beginning 1 week after the loading dose.
Safety and efficacy of lower doses or longer dosing intervals not established.
Prescribing Limits
Pediatric Patients
Cryopyrin-associated Periodic Syndromes
Sub-Q
Children 12–17 years of age: Maximum loading dose of 320 mg; maximum maintenance dose of 160 mg. Do not administer more frequently than once weekly. Maximum safe dosage not established.
Adults
Cryopyrin-associated Periodic Syndromes
Sub-Q
Do not administer more frequently than once weekly. Maximum safe dosage not established.
Special Populations
Hepatic Impairment
No specific dosage recommendations at this time.
Renal Impairment
No specific dosage recommendations at this time
Geriatric Patients
Dosage adjustment not required in patients ≥65 years of age.
Cautions for Rilonacept
Contraindications
-
No known contraindications.
Warnings/Precautions
Sensitivity Reactions
Hypersensitivity Reactions
Hypersensitivity reactions reported rarely.
If hypersensitivity reactions (e.g., rash, swollen face, difficulty breathing) occur, discontinue drug and initiate appropriate therapy as indicated.
Infectious Complications
IL-1 blockade may interfere with immune response to infections. Increased incidence of infections reported, including serious, potentially life-threatening infections (e.g., Mycobacterium intracellulare infection, sinusitis and bronchitis, Streptococcus pneumoniae meningitis).
Infections may occur at any time during therapy. Do not initiate rilonacept in patients with an active or chronic infection; discontinue therapy in patients who develop a serious infection.
May increase the risk of tuberculosis or other atypical or opportunistic infections. Evaluate and treat patients for latent tuberculosis prior to initiation of rilonacept therapy.
Immunosuppression and Malignancies
Effect on active and/or chronic infections and on development of malignancies not known. However, possible increased risk of malignancies with treatment with immunosuppressive agents, including rilonacept.
Immunization
Vaccine efficacy may be reduced; avoid live vaccines during rilonacept therapy. (See Vaccines under Interactions.)
Review vaccination status of all patients and administer all age-appropriate vaccines, including pneumococcal vaccine and influenza virus vaccine inactivated, prior to initiation of rilonacept therapy.
Lipid Abnormalities
Increases in total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations reported. Monitor lipoprotein concentrations (e.g., after 2–3 months) and initiate antilipemic therapy as needed based on cardiovascular risk factors and current clinical guidelines.
Immunologic Effects
Development of antibodies to rilonacept has been reported; however, no correlation between antibody activity and efficacy or safety of rilonacept.
Specific Populations
Pregnancy
Category C.
Lactation
Not known whether rilonacept is distributed into milk. Caution if used in nursing women.
Pediatric Use
Safety and efficacy not established in children <12 years of age.
Evaluated in 6 pediatric patients 12–16 years of age with CAPS; symptom scores and objective markers of inflammation improved in these children and adverse effects were similar to those observed in adults.
In animal studies, rilonacept may have contributed to alterations in bone ossification in the fetus; not known if rilonacept will affect bone development in pediatric patients. Pediatric patients receiving the drug should undergo appropriate monitoring for growth and development.
Geriatric Use
Efficacy, safety, and tolerability profile in those ≥65 years of age generally similar to that in younger adults. Fatal bacterial meningitis reported in a 71-year-old woman in a clinical study. (See Infectious Complications under Cautions.)
Hepatic Impairment
Pharmacokinetics not evaluated in patients with hepatic impairment.
Renal Impairment
Pharmacokinetics not evaluated in patients with renal impairment.
Common Adverse Effects
Injection site reactions (e.g., erythema, swelling, pruritus, mass, bruising, inflammation, pain, edema, dermatitis, discomfort, urticaria, vesicles, warmth, hemorrhage), upper respiratory tract infections, sinusitis, cough, hypoesthesia.
Interactions for Rilonacept
No formal drug interaction studies to date.
Drugs Metabolized by Hepatic Microsomal Enzymes
Increased levels of cytokines (e.g., IL-1) during chronic inflammation suppress the formation of CYP isoenzymes; drugs that bind to IL-1, including rilonacept, are expected to normalize CYP enzyme formation.
If rilonacept is initiated in a patient already receiving a CYP isoenzyme substrate that has a narrow therapeutic margin, monitor efficacy or concentrations of the concomitant drug and adjust dosage of the concomitant drug as needed.
Vaccines
Data not available on the effects of live virus vaccines in patients receiving rilonacept; administration of live vaccines not recommended. Data not available regarding whether rilonacept would affect the rate of secondary transmission of vaccine virus following administration of a live virus vaccine or regarding any other effect of vaccination on patients receiving the drug. (See Immunization under Cautions.)
Specific recommendations regarding the length of time to wait between discontinuance of rilonacept and administration of a live vaccine or the length of time to wait between administration of a live vaccine and initiation of rilonacept therapy not available.
Specific Drugs
Drug |
Interaction |
Comments |
---|---|---|
IL-1 blocking agents (e.g., anakinra, canakinumab) |
Potential pharmacologic interaction |
Concomitant use of rilonacept with other agents that block IL-1 or its receptors not recommended |
Immunosuppressive agents |
Potential for increased immunosuppressive effects |
|
TNF-blocking agents (e.g., adalimumab, etanercept, infliximab) |
Possible increased risk of serious infections and increased risk of neutropenia |
Concomitant use not recommended |
Warfarin |
Possible effect on warfarin metabolism; because increased levels of IL-1 during chronic inflammation may suppress formation of CYP isoenzymes, binding of rilonacept to IL-1 may normalize formation of CYP enzymes |
Monitor efficacy of warfarin; adjust warfarin dosage as needed |
Rilonacept Pharmacokinetics
Absorption
Bioavailability
Relative bioavailability following sub-Q administration is approximately 50%. Peak plasma concentrations achieved in approximately 3.6 days in healthy individuals. Steady-state concentrations reached by 6 weeks in patients with CAPS.
Onset
Improvement in symptom scores occurs within several days following initiation of therapy in most patients.
Special Populations
Following sub-Q administration for 24 weeks in pediatric patients 12–16 years of age with CAPS, mean trough drug concentrations were similar to those observed in adults with CAPS.
No significant difference in steady-state trough concentrations observed between geriatric patients and younger adults.
Distribution
Extent
Not known whether rilonacept is distributed into milk.
Elimination
Half-life
Terminal half-life approximately 8.6 days in adult patients.
Terminal half-life approximately 6.3 days in pediatric patients.
Special Populations
Pharmacokinetic data not available for patients with hepatic or renal impairment.
Effects of age, gender, or body weight on the pharmacokinetics of rilonacept not systematically evaluated.
Stability
Storage
Parenteral
Powder for Injection
2–8°C in original carton to protect from light.
Following reconstitution, store at room temperature, protect from light, and use within 3 hours. Discard unused portion of vial after a single withdrawal of drug.
Actions
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Dimeric fusion protein consisting of the ligand-binding domains of the extracellular portions of the human IL-1 type I receptor (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) linked in-line to the Fc portion of human immunoglobulin G1.
-
IL-1 receptor antagonist (IL-1Ra) used for the management of CAPS, including FCAS and MWS.
-
Blocks IL-1β signaling by acting as a soluble decoy receptor that binds IL-1β and prevents its interaction with cell surface receptors; also binds IL-1α and IL-1Ra to a lesser extent. Mutations in the NLRP-3 gene in patients with CAPS result in an overactive inflammasome, causing excessive release of activated IL-1β.
-
Results in sustained reductions in mean concentrations of SAA and CRP, indicators of inflammatory disease activity. Elevated SAA concentrations have been associated with the development of systemic amyloidosis in patients with CAPS.
Advice to Patients
-
Importance of providing a copy of the manufacturer’s patient information to all patients. Importance of discussing any questions pertaining to the manufacturer’s patient information.
-
Importance of instructing patient and/or caregiver regarding proper dosage and administration of rilonacept (including the use of aseptic technique and safe disposal of vials, needles, and syringes) if clinician has determined that the drug can safely and effectively be self-administered in the patient’s home by the patient, family member, or other responsible individual.
-
Risk of injection site reactions (e.g., erythema, swelling, pruritus, mass, bruising, inflammation, pain, edema, dermatitis, discomfort, urticaria, vesicles, warmth, hemorrhage). Importance of not injecting into areas where the skin is bruised, red, swollen, tender, or hard. Importance of informing clinician of any persistent injection site reaction.
-
Risk of serious, potentially life-threatening infection. Importance of informing clinicians promptly if any signs or symptoms of infection (e.g., fever, cough, flu-like symptoms, open sores) occur.
-
Risk of hypersensitivity reactions. Importance of immediately contacting a clinician or seeking immediate medical attention if any signs or symptoms of hypersensitivity (e.g., rash, swollen face, difficulty breathing) occur.
-
Possible changes in blood cholesterol and triglyceride concentrations; importance of adherence to laboratory appointment schedules.
-
Importance of reviewing vaccination status with clinician and receiving all age-appropriate vaccines prior to initiation of rilonacept therapy.
-
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription (e.g., IL-1 antagonists, TNF-blocking agents, immunizations, corticosteroids) or OTC drugs, dietary supplements, and/or herbal products, as well as any concomitant illnesses (e.g., active or chronic infections, asthma, diabetes mellitus).
-
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.
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Importance of informing patients of other important precautionary information. (See Cautions.)
Preparations
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.
Routes |
Dosage Forms |
Strengths |
Brand Names |
Manufacturer |
---|---|---|---|---|
Parenteral |
For injection, for subcutaneous use |
220 mg |
Arcalyst |
Regeneron |
AHFS DI Essentials™. © Copyright 2023, Selected Revisions February 1, 2011. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.
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