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Cromolyn Sodium (EENT) (Monograph)

Brand names: Crolom, Nasalcrom
Drug class: Antiallergic Agents

Medically reviewed by on Apr 10, 2024. Written by ASHP.


Mast-cell stabilizer.

Uses for Cromolyn Sodium (EENT)

Allergic Rhinitis

Self-medication for the symptomatic prevention and treatment of seasonal or perennial allergic rhinitis. Provides symptomatic relief of rhinorrhea, nasal congestion, sneezing, and postnasal drip.

Should not use as self-medication for the treatment of sinus infection [off-label], asthma [off-label], or cold symptoms [off-label].

Allergic Ocular Disorders

Symptomatic treatment of certain allergic ocular disorders (e.g., vernal keratoconjunctivitis, vernal conjunctivitis, vernal keratitis).

Has been used for the treatment of giant papillary conjunctivitis [off-label].

Cromolyn Sodium (EENT) Dosage and Administration



Administer intranasally or topically to the eye.

Administer at regular intervals.

Intranasal Administration

Parents or care providers must supervise use by young children. In very young children, an adult should administer nasal solution. Use care when inserting the nozzle into the nose to avoid injury.

Prior to administration, clear nasal passages by blowing the nose; administration of a topical nasal decongestant may be necessary. Inhale through the nose during administration.

For maximum therapeutic effect, initiate therapy before (e.g., ≤1–2 weeks before) and continue at regular intervals during the period of allergen exposure.

Ophthalmic Administration

Applied topically to the eye as an ophthalmic solution just inside the lower eyelid; patients should avoid applying the solution directly on the cornea.

To avoid contamination of dropper tip and solution, avoid touching the tip of the dispensing dropper or container to the eye, fingers, or any other surface.


Available as cromolyn sodium.

Nasal pump delivers 5.2 mg of cromolyn sodium per metered spray.

One drop of cromolyn sodium ophthalmic solution contains approximately 1.6 mg of cromolyn sodium.

Pediatric Patients

Allergic Rhinitis

Children ≥2 years of age: 1 spray (5.2 mg) in each nostril 3 or 4 times daily given at regular intervals (morning, noon, dinner, bedtime) for ≤12 weeks. When necessary, may be used up to 6 times daily.

Allergic Ocular Disorders

Children ≥4 years of age: 1 or 2 drops in each eye 4–6 times daily at regular intervals.

Do not exceed recommended frequency of administration.


Allergic Rhinitis

1 spray (5.2 mg) in each nostril 3 or 4 times daily (morning, noon, dinner, bedtime) for ≤12 weeks. When necessary, may be used up to 6 times daily.

Allergic Ocular Disorders

1 or 2 drops in each eye 4–6 times daily at regular intervals.

Cautions for Cromolyn Sodium (EENT)



General Precautions

Ocular Effects

Ophthalmic solution: Transient stinging or burning sensation may occur.

Respiratory Effects

Nasal solution: Transient nasal stinging and/or sneezing may occur immediately. Discontinue drug if nasal irritation occurs.

Specific Populations


Category B.


Not known whether cromolyn is distributed into milk. Use ophthalmic solution with caution. With nasal spray, consult a clinician prior to use.

Pediatric Use

Safety and efficacy of cromolyn sodium given as the nasal solution or ophthalmic solution not established in children <2 or <4 years of age, respectively.

Geriatric Use

Ophthalmic solution: No differences in safety or efficacy relative to younger adults.

Common Adverse Effects

Nasal solution: Nasal burning and stinging, nasal irritation, sneezing.

Ophthalmic solution: Transient ocular stinging or burning upon instillation.

Cromolyn Sodium (EENT) Pharmacokinetics



Approximately <7 or 0.03% absorbed following an intranasal dose or an ophthalmic dose, respectively.


Nasal solution: Improvement may take several days; best effect not seen for 1–2 weeks.

Ophthalmic solution: Improvement usually noted in a few days; treatment for up to 6 weeks sometimes needed to see improvement.



Does not cross most biologic membranes well.

Minimally crosses the placenta (<0.1%) and minimally distributed into milk (<0.001% of a dose) in animals.



81 minutes.




Nasal Solution

20–25°C; protect from light.


Ophthalmic Solution

20–25°C or 15–30°C, depending on manufacturer; protect from light. Store in original carton.


Advice to Patients


Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Cromolyn Sodium


Dosage Forms


Brand Names




5.2 mg/metered spray*

Cromolyn Sodium Nasal Spray (with benzalkonium chloride 0.01% and edetate disodium 0.1%)


Nasalcrom (with benzalkonium chloride 0.01% and edetate disodium 0.1%)





Crolom (with benzalkonium chloride 0.01% and edetate disodium 0.1%)

Bausch & Lomb

Cromolyn Sodium Ophthalmic Solution (with benzalkonium chloride 0.01% and edetate disodium 0.1%)


AHFS DI Essentials™. © Copyright 2024, Selected Revisions April 10, 2024. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration.

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