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Does Vyepti cause weight gain?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Dec 2, 2023.

Official Answer by Drugs.com

No, weight gain was not seen in safety studies of Vyepti lasting up to one year long. In general, Vyepti is well tolerated, with less than 2% of patients dropping out of clinical studies due to side effects.

What side effects do I expect to see with Vyepti?

Safety studies included over 2,000 adult patients receiving either the 100 or 300 mg dose of Vyepti for migraine prevention.

The most common side effects were common cold symptoms like stuffy nose and scratchy throat (6% to 8% of patients taking Vyepti vs. 6% placebo) and allergic (hypersensitivity) reactions (1% to 2% of patients taking Vyepti vs. 0% placebo).

Some allergic reactions, such as anaphylaxis, may be serious. If you have symptoms of an allergic reaction, contact your doctor or emergency medical care right away. These symptoms can include:

How is Vyepti given?

The recommended dose is 100 mg intravenously (IV) given every 3 months. Some patients may benefit from a higher dose of 300 mg. The infusion takes about 30 minutes and is only given by your healthcare provider.

Vyepti (eptinezumab-jjmr) is the first FDA-approved IV treatment for migraine prevention in adults.

Related questions

How well does Vyepti work to prevent migraine?

In two Phase 3 clinical studies of Vyepti (PROMISE-1 in episodic migraine and PROMISE-2 in chronic migraine), researchers were looking to see how many fewer days of migraine headaches patients had over a 12-week period. At the start of the study, on average, patients had 8.6 migraine days per month.

Vyepti also exhibited a benefit over placebo for both the 100 and 300 mg doses of Vyepti as early as the first day after treatment. The percentage of patients experiencing a migraine was lower for Vyepti than with placebo for most of the first 7 days.

Vyepti is classified as a humanized monoclonal antibody that binds to calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor.

Related: List of CGRP migraine medications

References

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How long do Vyepti infusions take?

Vyepti intravenous (IV) infusions take about 30 minutes and are given 4 times per year (every 3 months). You will receive the infusion at your doctor’s office or at a special infusion center, and the total time spent there may be longer than 30 minutes. Continue reading

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Obesity is a major risk factor for covid-19 and people who are obese are more likely than those who are not obese to contract Covid-19 at a younger age, develop severe Covid-19, require hospitalization, oxygen, mechanical ventilation, intubation, or admission into ICU, end up in hospital sooner, or die from Covid-19. Continue reading

Mounjaro vs Ozempic: Which is right for you?

Mounjaro and Ozempic are prescription medicines used alongside diet and exercise to help control blood sugar (glucose) levels in adults with type 2 diabetes. Ozempic is also approved to lower the risk of a major cardiovascular event (like a heart attack or stroke) in patients with type 2 diabetes, as well as to reduce the risk of worsening kidney disease and heart-related death in patients with type 2 diabetes. Mounjaro has not yet received these indications, although studies are ongoing.

In a large, 2024 retrospective study in adults with overweight or obesity and treated for type 2 diabetes, Mounjaro led to at least a 5% weight loss within one year in 81.8% of adults compared to 66.5% of those using Ozempic. Continue reading

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