What type of drug is Ozempic (semaglutide)?
Ozempic (semaglutide) belongs to a class of drugs called glucagon-like peptide 1 (GLP-1) analogs.
Ozempic is used in adults with type 2 diabetes to:
- Control blood sugar levels when combined with diet and exercise
- Lower the risk of serious heart problems in those who also have heart disease
- Protect the kidneys in those who also have chronic kidney disease by:
- Slowing down kidney damage
- Reducing the risk of kidney failure
- Lowering the risk of death from heart problems.
What is GLP-1?
GLP-1 is an incretin hormone, which is inactivated by dipeptidyl peptidase-4 (DPP-4). Glucose-dependent insulinotropic polypeptide (GIP) is another such hormone.
GLP-1 and GIP stimulate the secretion of insulin after glucose is consumed, which helps to regulate blood sugar levels. They work via a process known as the incretin effect. In people with type 2 diabetes, this process may not work so well or may no longer work at all.
Related questions
- Mounjaro vs Ozempic: Which is right for you?
- Ozempic Side Effects to Watch For
- What are the long-term side effects of Ozempic?
What are GLP-1 analogs?
GLP-1 analogs, such as Ozempic, are medications that increase levels of incretins. They are also known as incretin mimetics.
They work by increasing the amount of insulin available when it is needed and reducing the amount of unnecessary glucose being produced by the liver.
GLP-1 analogs have a number of benefits including:
- Delaying gastric emptying - reducing the rate at which the stomach digests food and empties
- Reduce appetite
- Promoting weight loss
- Lowering blood pressure
- Lowering cholesterol
GLP-1 analogs also provide additional cardiovascular-related and other benefits.
Most GLP-1 analogs are injected. Ozempic is injected once a week into the abdomen, thigh or upper arm using an injection pen. However, in September 2019, the US Food and Drug Administration (FDA) approved the first tablet version of a GLP-1 analog called Rybelsus. Like Ozempic, Rybelsus also contains semaglutide.
References
- Ozempic Prescribing Information. https://www.novo-pi.com/ozempic.pdf
- Diabetes UK. GLP-1 analogues. Available from: https://www.diabetes.org.uk/guide-to-diabetes/managing-your-diabetes/treating-your-diabetes/tablets-and-medication/incretin-mimetics. [Accessed February 2, 2021].
Read next
How do Ozempic, Mounjaro, Wegovy, Zepbound compare for weight loss?
Ozempic, Mounjaro, Wegovy and Zepbound can all lead to long-term weight loss, but only Wegovy and Zepbound are approved by the FDA for this use. In studies, Zepbound has led to a 21% weight loss in adults using the highest dose, while Wegovy has led to about a 15% weight loss. Continue reading
How long does it take for Ozempic to work?
Your blood glucose (sugar) levels should start to fully decline within the first week after you start using Ozempic (semaglutide) at your regular dose. However, the full effect can take 8 weeks or longer, as this is a long-acting medication that is injected only once per week. Continue reading
Wegovy vs Ozempic: Which is Right for You?
Both Wegovy and Ozempic contain semaglutide, but Wegovy is prescribed for long-term weight management while Ozempic is used to control blood sugar levels in type 2 diabetes and help protect kidney function. They both lower the risk for heart-related complications, but they differ in other approved uses, doses, target populations and costs. Continue reading
See also:
Aimovig
Learn about Aimovig (erenumab-aooe) a once-monthly, injectable medication that can be ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Repatha
Repatha is used to lower high cholesterol alongside dietary changes and to reduce the risk of major ...
Nurtec ODT
Nurtec ODT (rimegepant) is used to treat acute migraines and prevent episodic migraines, by ...
Vyepti
Vyepti (eptinezumab-jjmr) is used for the preventive treatment of migraine. Includes Vyepti ...
Depakote
Depakote is used to treat various types of seizure disorders. Learn about side effects ...
Topamax
Topamax (topiramate) is used to prevent seizures in adults and children and to prevent migraine ...
Emgality
Emgality (galcanezumab-gnlm) is a CGRP antagonist for the preventive treatment of migraine and for ...
Inderal
Inderal (propranolol) is used to treat angina, high blood pressure and heart rhythm disorders ...
Related medical questions
- How many doses are in an Ozempic pen?
- Do Ozempic, Wegovy, Mounjaro & Zepbound cause hair loss?
- How does Ozempic work for weight loss?
- What happens when you stop taking Ozempic?
- Can you switch between Ozempic and Mounjaro?
- Does Ozempic need to be refrigerated?
- Saxenda vs Ozempic: For Weight Loss?
- Will my insurance cover the cost of Ozempic?
- Can you buy Ozempic over the counter?
- When is the best time of day to take Ozempic?
- Why am I not losing weight on Ozempic?
- Does Ozempic cause muscle loss and how to prevent it?
- Where and how should Ozempic be injected?
- Rybelsus vs Ozempic for weight loss: Which to choose?
- Are there natural alternatives to Ozempic for weight loss?
- Ozempic Face: What causes it and how to prevent it?
- How long does Ozempic last in your system?
- Do GLP-1 drugs like Ozempic and Mounjaro cause sulfur burps?
- How long can you stay on Ozempic?
- How does Ozempic affect blood pressure?
- Is Ozempic better than metformin?
- Trulicity vs Ozempic: Which is right for you?
- Taking Ozempic: What foods should you avoid?
Drug information
- Ozempic Information for Consumers
- Ozempic prescribing info & package insert (for Health Professionals)
- Side Effects of Ozempic (detailed)
- Ozempic user reviews (1,544)
Related support groups
- Ozempic (107 questions, 223 members)
- Diabetes, Type 2 (502 questions, 1,428 members)
- Cardiovascular Risk Reduction (100 questions, 28 members)