What is the safest diabetes medication?
Medically reviewed by Drugs.com. Last updated on Jan 10, 2025.
Most experts consider metformin to be the safest medicine for type 2 diabetes because it has been used for many decades, is effective, affordable, and safe. Metformin is recommended as a first-line treatment for type 2 diabetes by the American Diabetes Association (ADA).
References
- Type 2 diabetes: Which medication is best for me? Harvard Health Publishing School. November 5, 2020. https://www.health.harvard.edu/blog/type-2-diabetes-which-medication-is-best-for-me-2020110521256
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How long does metformin take to work?
Metformin will usually start lowering your blood sugar (glucose) levels in the first week of treatment, but it may take 2 to 3 months to see its full effect. Metformin is a preferred initial oral treatment for people with type 2 diabetes, and is usually taken on a long-term basis. It may be combined with other blood glucose-lowering treatments, if needed. Continue reading
When is the best time to take metformin?
Metformin should be taken after having a meal or eating food, especially when you are first starting treatment. This can help reduce any stomach side effects like nausea, vomiting, diarrhea or gas. These side effects generally go away within a few weeks after starting treatment. Continue reading
Why does metformin cause diarrhea?
Metformin causes diarrhea by changing gut bacteria, affecting bile acid absorption, blocking water absorption in the intestines, and increasing gut-stimulating hormones. These combined effects make stools looser and more frequent.
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Drug information
- Metformin Information for Consumers
- Metformin prescribing info & package insert (for Health Professionals)
- Side Effects of Metformin (detailed)
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