Does Prolia cause weight gain?
Prolia (denosumab) has not been associated with weight gain in clinical studies. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. Speak with your doctor if you have any side effect that bothers you or that does not go away.
In studies, peripheral edema (fluid retention in the areas like the arms or legs) was reported in 4.9% of patients compared to 4% receiving a placebo. Edema may occur at the administration site. Swelling may also occur in the facial area due to a serious allergic reaction. Get emergency medical help right away if you are having a serious allergic reaction.
What are the most common side effects of Prolia?
Back pain, joint pain and pain in the legs and arms are some of the most common side effects reported with Prolia (denosumab).
The most common side effects in women who are being treated for osteoporosis after menopause are:
- back pain
- pain in your arms and leg
- high cholesterol
- muscle pain
- bladder infection
The most common side effects in men with osteoporosis are:
- back pain
- joint pain
- common cold (runny nose or sore throat)
The most common side effects in patients with osteoporosis due to corticosteroid use (like prednisone) are:
- back pain
- high blood pressure
- lung infection (bronchitis)
- headache
The most common side effects in patients receiving certain treatments for prostate or breast cancer are:
- joint pain
- back pain
- pain in your arms and legs
- muscle pain
These are not all of the possible side effects of Prolia. Review Prolia side effects (in more detail) here.
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Why is Prolia prescribed?
Prolia is classified as a RANK ligand (RANKL) inhibitor and is approved by the FDA:
- for the treatment of postmenopausal women with osteoporosis at high risk for fracture
- for the treatment of bone loss in patients with prostate or breast cancer undergoing hormone ablation therapy
- as a treatment to increase bone mass in men with osteoporosis at high risk for fracture
- for the treatment of osteoporosis due to use of corticosteroid medicines (such as prednisone) in men and women at high risk of fracture.
This is not all the information you need to know about Prolia (denosumab) for safe and effective use and does not take the place of your doctor’s directions. Review the full Prolia product information and discuss this information and any questions you have with your doctor or other health care provider.
References
- Prolia (denosumab) product information. Amgen Inc. Accessed March 19, 2022 at https://www.pi.amgen.com/~/media/amgen/repositorysites/pi-amgen-com/prolia/prolia_pi.pdf
Read next
Evenity vs Prolia: Which is right for you?
Evenity (romosozumab-aqqg) and Prolia (denosumab) are two injectable medications that help lower the risk of bone fracture. When deciding which treatment option is best for you, it is important to consider factors such as who these medications are approved for, dosing, and side effects. Continue reading
Does Prolia increase bone density?
Prolia (denosumab) does increase bone density. Prolia works by targeting a molecule called RANKL that osteoclasts need to work. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. Continue reading
Can you drink alcohol while taking Prolia?
While there are no known drug interactions between Prolia (generic name: denosumab) and alcohol, but you should check with your doctor first before you drink. Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. Continue reading
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Drug information
- Prolia Information for Consumers
- Prolia prescribing info & package insert (for Health Professionals)
- Side Effects of Prolia (detailed)
- Prolia user reviews (375)
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