Can Ozempic cause personality changes​ or depression?

Ozempic (semaglutide) is a GLP-1 receptor agonist primarily prescribed for type 2 diabetes and, off-label, for weight loss. Recently, there have been reports and discussions about whether Ozempic can cause personality changes or depression. While there have been case reports and anecdotal evidence on social media, the majority of scientific reviews have not found an association between Ozempic and suicidal thoughts or actions.

Evidence on Personality Changes and Depression From Ozempic

Mood changes, such as depression, are not mentioned as common side effects in the manufacturer labeling for Ozempic. Interestingly, there is a warning about suicidal behavior and ideation in the Wegovy package insert (another brand name for semaglutide approved for weight loss), but it is based on reports of this side effect with other weight management products. Below is a summary of research on mood changes from Ozempic:

• One study revealed that users have reported anxiety, depression, and other mental health problems related to Ozempic on social media platforms. Some describe these effects as "Ozempic personality," even though the term is not scientifically established.
• The FDA acknowledges reports of new or worsening depression, suicidal thoughts, or unusual mood changes in patients taking GLP-1 drugs and advises patients to seek medical attention if these occur. So far in their review, they have not found evidence that GLP-1 drugs like Ozempic cause suicidal thoughts or actions. Monitoring by the FDA is ongoing.
• A recent 12-month study found no increased risk of adverse neuropsychiatric outcomes with semaglutide compared to other diabetes medications.
• In 2024, the EMA has stated that available evidence does not indicate a causal association between GLP-1 agonists like semaglutide and suicidal thoughts or actions. This was following a review of electronic health records and other available evidence from different studies.
• An analysis of the World Health Organization Vigibase revealed more reports of suicidal thoughts by people taking semaglutide compared to other diabetes medications. However, this was more common in people already taking medications to treat anxiety or depression.

Related questions

• Mounjaro vs Ozempic: Which is right for you?
• Ozempic Side Effects to Watch For
• How do Ozempic, Mounjaro, Wegovy, Zepbound compare for weight loss?

When to Get Medical Help

Monitor mood and behavior closely when starting Ozempic, and report any new or worsening depression, anxiety, or unusual mood changes to a healthcare professional immediately.

Do not discontinue Ozempic without medical advice, as untreated diabetes or obesity can also impact mental health.

Summary

While some patients taking Ozempic report mood changes, anxiety, or depressive symptoms that they interpret as personality changes, these effects are not widely documented in clinical trials or official prescribing information. Large-scale studies have not confirmed a direct causal link. Patients experiencing mood changes should promptly discuss these symptoms with their healthcare provider to ensure appropriate management.