Can Nucala cause weight gain?
No, weight gain has not been reported as a side effect of Nucala during clinical trials. Corticosteroids such as betamethasone, budesonide, or prednisone, are known to cause weight gain. However, Nucala is not a corticosteroid, it is a biologic that works by binding to cytokines that are small secreted proteins that are involved in cell signaling and interactions.
However, anecdotally, some people have reported a small amount of weight gain on blog sites, although equally as many people report weight loss as well, usually because they no longer need to take as much prednisone.
If you do think you are gaining weight on Nucala, keep a diary that documents your daily diet, amount of exercise, and daily weight gain. Try to eat a healthy diet and exercise regularly. If there is a clear pattern of weight gain, talk with your doctor.
The most common side effects reported with Nucala were:
- Headaches
- Injection site reactions (redness, pain, itching, or swelling at the injection site)
- Back pain
- Tiredness.
Rarely, allergic reactions may occur with Nucala and it may precipitate Shingles.
Nucala (mepolizumab) is approved:
- As an add-on maintenance treatment for severe eosinophilic asthma in adults and children aged 6 and older. Eosinophils are a type of white blood cell and this type of asthma affects 5% of all asthmatics
- For inadequately controlled chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype in adults as add-on maintenance treatment
- For the treatment of adult patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
- For the treatment of patients ≥12 years with hypereosinophilic syndrome (HES)
- As an add-on maintenance treatment of chronic rhinosinusitis with nasal polyps in adult patients 18 years of age and older with inadequate response to nasal corticosteroids.
Related questions
- How does the Nucala copay card work and do I qualify?
- How long does it take for Nucala to work?
- How does Nucala (mepolizumab) work? What is the MOA?
References
- Nucala Prescribing Information https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Nucala/pdf/NUCALA-PI-PIL-IFU-COMBINED.PDF
Read next
Can Nucala be self-administered? How is it injected?
Yes, Nucala can be self-administered. Nucala is available as a prefilled syringe or autoinjector that can be self-administered after a doctor has shown you how to administer it. 99% of people can successfully self-administer the Nucala prefilled syringe and 89-95% can successfully administer the Nucala autoinjector.
Continue reading
What is Nucala (mepolizumab) used for and how is it given?
Nucala (mepolizumab) is a biologic therapy used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome (HES). It is given by subcutaneous injection every four weeks. Continue reading
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Obesity is a major risk factor for covid-19 and people who are obese are more likely than those who are not obese to contract Covid-19 at a younger age, develop severe Covid-19, require hospitalization, oxygen, mechanical ventilation, intubation, or admission into ICU, end up in hospital sooner, or die from Covid-19. Continue reading
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