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Is microdosing Ozempic safe and effective for weight loss?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on March 30, 2025.

Official answer

by Drugs.com

There is limited evidence on whether microdosing Ozempic (semaglutide) is safe or effective for weight loss. Ozempic should only be used under the supervision of a healthcare provider and according to prescribed dosing instructions.

What is Microdosing Ozempic?

Microdosing refers to injecting smaller amounts of Ozempic than the typical prescribed dose. Some individuals attempt this to:

  • Extend their Ozempic supply
  • Reduce side effects
  • Maintain weight loss
  • Lose a small amount of weight
  • Offset the high cost of medication

However, microdosing Ozempic is not FDA-approved, and its effectiveness for weight loss has not been established.

Is Microdosing Ozempic Safe?

There are several risks associated with microdosing Ozempic, including:

  • Dosing errors: Adjusting the Ozempic pen incorrectly or drawing medication up yourself could lead to unsafe doses.
  • Compounded Ozempic concerns: Some people microdose using compounded semaglutide, which is not FDA-approved and may contain inaccurate doses or harmful ingredients.
  • Injection safety: Always use a new needle for each dose to prevent infection.

Microdosing should only be done under medical supervision with proper guidance on dosing and injection techniques.

Related questions

Is Microdosing Ozempic Effective?

Currently, there are no placebo-controlled studies proving the effectiveness of microdosing Ozempic for weight loss. While some individuals report reduced appetite with lower doses, these claims are anecdotal.

Your healthcare provider can help determine the most appropriate Ozempic dose based on your weight loss goals and medical needs.

This is not all the information you need to know about Ozempic (semaglutide) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

Hibbert, C., 2024. Does microdosing Ozempic work? What are experts saying about diabetes drug also used for weight loss? Northeastern Global News. Accessed 02/19/2025 at https://news.northeastern.edu/2024/10/18/microdosing-ozempic/

Ozempic [package insert]. Updated January 2025. Novo Nordisk. Accessed 02/19/2025 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79

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