How do you use Intrarosa vaginal inserts?

Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 10, 2025.

Official Answer by Drugs.com

Intrarosa (prasterone) vaginal inserts are a bullet-shaped insert or suppository that are inserted into the vagina using an applicator.

Intrarosa contains a steroid medication and it is used to treat moderate to severe dyspareunia - the medical term for difficult or painful sexual intercourse - which is a symptom of vaginal and vulvar atrophy caused by menopause.

What to know before using Intrarosa vaginal inserts

Use Intrarosa once a day at bedtime.
Intrarosa vaginal inserts are supplied in a strip containing 7 inserts. To remove one insert tear along the perforated line.
Intrarosa vaginal inserts are supplied with the applicators you need to insert them into the vagina.
Only use each applicator once.
Before using the applicator empty your bladder and wash your hands.
Store Intrarosa at 41°F to 86°F (5°C to 30°C). It can be stored at room temperature or in the refrigerator. It should not be left in hot places, such as a car, in the sun or next to the heater because it will melt.

The 7 steps to using Intrarosa vaginal inserts

Remove the applicator from the package then pull back on the plunger until it stops. This will activate the applicator. Place the applicator on a clean surface.
Pick up the Intrarosa vaginal insert and slowly pull the plastic tabs away from one another while keeping the insert between your fingers. Remove the insert carefully from the plastic wrap, taking care not to drop it on a surface that is not clean. If it is dropped onto an unsanitary surface it should be replaced with a new insert.
Place the flat end of the insert into the open end of the applicator.
Hold the applicator between your middle finger and thumb, leaving your index finger free to press the plunger once the applicator is inserted.
Lie or stand in a comfortable position.
Gently insert the applicator into the vagina as far as it will comfortably go. Do not force the insert and applicator.
Use your index finger to press the plunger and release the insert into the vagina, then remove the applicator and throw it away.

References

Food and Drug Administration (FDA). Intrarosa. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208470s001lbl.pdf. [Accessed February 17, 2021].
Intrarosa. Using Intrarosa. Available from: https://us.intrarosa.com/using-intrarosa. [Accessed February 17, 2021].

Can magnesium help with menopause symptoms?

A placebo-controlled study showed that 800 mg to 1,200 mg per day of magnesium oxide did not have a significant effect in reducing hot flash symptoms in menopausal women with a history of breast cancer. A smaller study did show a positive effect with 400 mg to 800 mg, but did not include a placebo (control) group. Further research is needed in a more generalized population.

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How do you use Intrarosa vaginal inserts?

What to know before using Intrarosa vaginal inserts

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