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What is the difference between Xelpros and Xalatan?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Dec 29, 2022.

Official answer


The Xelpros brand of latanoprost eye drops does not contain the preservative benzalkonium chloride (BAK), but the Xalatan brand does. Instead, Xelpros uses potassium sorbate as a preservative. If you prefer no preservative, Iyuzeh was approved in Dec. 2022 as the first preservative-free formulation of latanoprost.

What is latanoprost?

  • Latanoprost is a prostaglandin analogue used to reduce elevated intraocular (inside the eye) pressure in patients with open-angle glaucoma or ocular hypertension.
  • Latanoprost lowers the intraocular pressure (IOP) by increasing the outflow of aqueous humor.
  • Xelpros, Xalatan and Iyuzeh are all brand name eye drop products for latanoprost ophthalmic 0.005%. Latanoprost is available as a generic.

How fast does it work?

Elevated IOP is a major risk factor for optic nerve damage and vision loss in glaucoma The reduction in IOP begins about about 3 to 4 hours after instilling latanoprost drops, the maximum effect is reached at 8 to 12 hours, and reduction in IOP lasts for at least 24 hours.

Does benzalkonium chloride affect contacts?

Yes, benzalkonium chloride can be absorbed and may change the color of your contacts. Studies have shown that eye drops containing BAK can also cause allergic reactions, dry eye, eye redness, and other side effects in some patients.

The manufacturers of Xelpros, Xalatan and Iyuzeh each recommend that you remove your contact lenses prior to the instillation of the eye drops, even though only Xalatan contains benzalkonium chloride. Your contact lenses may be reinserted 15 minutes after use.

This is not all the information you need to know about Xelpros, Xalatan or Iyuzeh (latanoprost) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.


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