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How is Activase (alteplase) given/administered?

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 8, 2024.

Official Answer by Drugs.com

How Activase is given or administered depends upon the patient’s weight and what it is being used to treat (such as a stroke, pulmonary embolism, or myocardial infarction). For example, when used to treat a heart attack (myocardial infarction), there are two Activase dose regimens, an accelerated and a 3-hour regimen, with different recommendations depending on if the patient is over 67kg or not.

FDA-approved indications for Activase include pulmonary embolism, myocardial infarction with ST-segment elevation (STEMI), ischemic stroke when given within 3 hours of the start of symptoms, and re-establishment of patency in occluded intravenous (IV) catheters.

Recommended administration of Activase for pulmonary embolism (PE)

Recommended administration of Activase for myocardial infarction with ST-segment elevation (STEMI) (heart attack)

Accelerated regimen

Related questions

3-hour regimen

Recommended administration of Activase for Acute Ischemic Stroke

Recommended administration of Activase for IV Catheter Occlusion


References
  • Activase (alteplase) Updated 10/2020. Genentech, Inc. https://www.drugs.com/pro/activ

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