Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- disulfiram
- Thioplex (thiotepa)
Interactions between your drugs
thiotepa disulfiram
Applies to: Thioplex (thiotepa), disulfiram
Coadministration of thiotepa may increase plasma concentrations of drugs that are primarily metabolized by CYP450 2B6. Thiotepa has been shown to be a weak inhibitor of CYP450 2B6 in vitro, although drug interactions studies are not available, and the clinical significance is unknown. Product labeling for the specific CYP450 2B6 substrate should be consulted for additional recommendations and monitoring for increased adverse effects when used concomitantly with thiotepa may be warranted.
References (4)
- (2023) "Product Information. Thiotepa (thiotepa)." Meitheal Pharmaceuticals Inc.
- (2023) "Product Information. Tepadina (thiotepa)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 3
- (2022) "Product Information. Thiotepa (thiotepa)." MSN Laboratories Europe Ltd
- (2021) "Product Information. Tepadina (thiotepa)." Adienne SA
Drug and food interactions
disulfiram food
Applies to: disulfiram
CONTRAINDICATED: Consumption of ethanol during treatment with disulfiram may cause flushing, nausea, blurred vision, dyspnea, tachypnea, tachycardia, and hypotension. Death has been reported. The mechanism is probably related to inhibition of aldehyde dehydrogenase, the enzyme responsible for the oxidation of acetaldehyde to acetyl CoA. Accumulation of acetaldehyde probably results.
MANAGEMENT: Ethanol should be avoided in patients receiving disulfiram.
References (3)
- Jones RO (1949) "Death following the ingestion of alcohol in an antabuse treated patient." Can Med Assoc J, 60, p. 609-12
- Stoll D, King LE (1980) "Disulfiram-alcohol skin reaction to beer-containing shampoo." JAMA, 244, p. 2045
- van Ieperen L (1984) "Sudden death during disulfiram-ethanol reaction." S Afr Med J, 66, p. 165
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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