Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- diflunisal
- probenecid
Interactions between your drugs
probenecid diflunisal
Applies to: probenecid, diflunisal
Probenecid may increase the pharmacologic and toxic effects of diflunisal in some patients by inhibition of hepatic metabolism and displacement from plasma protein-binding sites. Increased diflunisal concentrations may result. The clinical significance has not been reported. When these drugs are combined, patients should be observed for diflunisal toxicity such as nausea, vomiting, drowsiness, tinnitus, tachycardia, sweating, or confusion.
References (3)
- Diamond JS, Paolino JS (1973) "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest, 52, p. 1491-9
- Regal RE (1987) "Aspirin and uricosurics: interaction revisited." Drug Intell Clin Pharm, 21, p. 219-20
- Macdonald JI, Wallace SM, Herman RJ, Verbeeck RK (1995) "Effect of propenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal." Eur J Clin Pharmacol, 47, p. 519-23
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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