Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- clopidogrel
- fosphenytoin
Interactions between your drugs
fosphenytoin clopidogrel
Applies to: fosphenytoin, clopidogrel
In vitro studies have shown that high concentrations of clopidogrel inhibit CYP450 2C9 isoenzymes. The metabolism of drugs which are substrates for this enzyme may be decreased, potentiating toxicity of the substrate drug. The clinical significance and magnitude of this interaction is not known. Dose adjustments may be necessary if an interaction is suspected.
References (1)
- (2001) "Product Information. Plavix (clopidogrel)." Bristol-Myers Squibb
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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