Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Insta-Char with Sorbitol (charcoal / sorbitol)
- leflunomide
Interactions between your drugs
charcoal leflunomide
Applies to: Insta-Char with Sorbitol (charcoal / sorbitol), leflunomide
GENERALLY AVOID: A significant decrease in M1, the active metabolite of leflunomide, has resulted when cholestyramine or activated charcoal is administered to patients receiving leflunomide. Administration of cholestyramine 8 grams 3 times a day has resulted in a 40% decrease in plasma levels of M1 in a 24 hour period.
MANAGEMENT: Coadministration of these drugs is not recommended.
References (1)
- (2001) "Product Information. Arava (leflunomide)." Hoechst Marion Roussel
Drug and food interactions
leflunomide food
Applies to: leflunomide
GENERALLY AVOID: The consumption of alcohol during therapy with leflunomide may potentiate the risk of liver injury. Leflunomide has been associated with hepatotoxicity, including elevated liver transaminases, hepatitis, jaundice/cholestasis, hepatic failure, and acute hepatic necrosis,
MANAGEMENT: Patients should be advised to avoid excessive alcohol use during leflunomide treatment.
References (3)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Cerner Multum, Inc. "Australian Product Information."
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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