Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- landiolol
- Prostigmin Bromide (neostigmine)
Interactions between your drugs
neostigmine landiolol
Applies to: Prostigmin Bromide (neostigmine), landiolol
MONITOR: Severe bradycardia and hypotension may develop during concomitant administration of some beta-blockers and anticholinesterase agents. The mechanism is unknown but may involve additive effects. Data have been conflicting. Some studies have reported no significant changes.
MANAGEMENT: The patient's hemodynamic status should be monitored during coadministration. Patients should be advised to notify their physician if they experience syncope, orthostasis, or a slow pulse.
References (1)
- Eldor J, Hoffman B, Davidson JT (1987) "Prolonged bradycardia and hypotension after neostigmine administration in a patient receiving atenolol." Anaesthesia, 42, p. 1294-7
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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