Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- bupivacaine / meloxicam
- darunavir
Interactions between your drugs
meloxicam darunavir
Applies to: bupivacaine / meloxicam, darunavir
Coadministration with potent or moderate CYP450 3A4 inhibitors may increase the plasma concentration of meloxicam. In vitro studies indicate that meloxicam is primarily metabolized by CYP450 2C9 with a minor contribution from CYP450 3A4. Clinical studies relating to this interaction are unavailable. NSAID related side effects and toxicity may occur with this combination.
References (5)
- (2025) "Product Information. Symbravo (meloxicam-rizatriptan)." Axsome Therapeutics, Inc.
- (2025) "Product Information. Meloxicam (meloxicam)." Lupin Pharmaceuticals Inc
- (2024) "Product Information. Meloxicam (meloxicam)." Flamingo Pharma (UK) Ltd
- (2017) "Product Information. Meloxicam (meloxicam)." Teva Canada Limited
- (2024) "Product Information. Meloxicam (WGR) (meloxicam)." GM Pharma International Pty Ltd
Drug and food interactions
darunavir food
Applies to: darunavir
ADJUST DOSING INTERVAL: Food enhances the absorption and oral bioavailability of darunavir administered in combination with low-dose ritonavir. The mechanism is unknown. When administered with food, the peak plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) of darunavir were approximately 30% higher than when administered in the fasting state. Darunavir exposure was similar for the range of meals studied. The total caloric content of the various meals evaluated ranged from 240 Kcal (12 grams fat) to 928 Kcal (56 grams fat).
MANAGEMENT: To ensure maximal oral absorption, darunavir coadministered with ritonavir should be taken with food. The type of food is not important.
References (1)
- (2006) "Product Information. Prezista (darunavir)." Ortho Biotech Inc
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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