Drug Interaction Report

Talk to your doctor before using bosentan together with saquinavir. Combining these medications may increase the blood levels of bosentan to dangerous levels, increasing the risk of side effects. You may need a dose adjustment if you have been receiving bosentan and are starting treatment with saquinavir, or vice versa. In addition, you may need more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food can enhance the levels of saquinavir in your body. Saquinavir should be taken with meals or within 2 hours after eating. This will make it easier for your body to absorb the medication. Grapefruit can raise the levels of saquinavir in your body. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.