Drug Interaction Report

Medications like semaglutide can delay the emptying of food and liquid from your stomach. If you are scheduled for a surgery or procedure that requires general anesthesia with sevoflurane, you may have residual contents in your stomach despite following the fasting instructions provided by your doctor. This can increase the risk of regurgitation during anesthesia and having the stomach contents inhaled into the lungs, which can cause inflammation or injury to the lungs, pneumonia, or even death. Therefore, it is important to let your doctor know prior to your surgery or procedure that you are receiving treatment with semaglutide. Depending on your condition and your individual circumstances, the doctor may instruct you to temporarily withhold treatment with semaglutide in advance, or they make take extra precaution during anesthesia and your surgery/procedure to minimize the risks. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interfere with the safety of your anesthesia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral semaglutide be taken 30 minutes before first food, beverage, or other oral medications of the day with no more than 4 ounces of plain water. You may experience more side effects including nausea, vomiting, and diarrhea if you fast longer than 30 minutes after the semaglutide dose. Talk to a healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.