Drug Interaction Report

Using dabrafenib together with trametinib may increase your risk of experiencing severe skin reactions, hemorrhages, blood clots and serious febrile events. You may need dose adjustments and frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience red or purple rash; fever; severe weakness, unusual bleeding or bruising; shortness of breath, chest pain or arm or leg swelling. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food may delay and reduce the absorption of dabrafenib, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take dabrafenib at least 1 hour before or 2 hours after a meal.

Food may delay and reduce the absorption of trametinib, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take trametinib at least 1 hour before or 2 hours after a meal.

The recommended maximum number of medicines in the 'multikinase inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'multikinase inhibitors' category:

• dabrafenib
• trametinib

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.