Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Erivedge (vismodegib)
- nelfinavir
Interactions between your drugs
nelfinavir vismodegib
Applies to: nelfinavir, Erivedge (vismodegib)
MONITOR: Coadministration with inhibitors of P-glycoprotein may increase the plasma concentrations of vismodegib, which has been shown in vitro to be a substrate of the efflux transporter. The potential for increased pharmacologic effects of vismodegib, including adverse effects such as muscle spasm, alopecia, dysgeusia/ageusia, weight loss, fatigue, nausea, vomiting, diarrhea, decreased appetite, constipation and arthralgia, should be considered.
MANAGEMENT: Caution is advised if vismodegib is used in combination with P-glycoprotein inhibitors.
References (2)
- (2012) "Product Information. Erivedge (vismodegib)." Genentech
- Cerner Multum, Inc. (2015) "Canadian Product Information."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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