Drug Interaction Report
1 drug interaction and 11 additional warnings found for the following 2 drugs:
- attapulgite
- Depen (penicillamine)
Drug interactions
Moderate drug interactions
Moderate:penicillAMINE attapulgite
Applies to: Depen (penicillamine), attapulgite
PenicillAMINE and attapulgite should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of penicillAMINE into the bloodstream and reduce its effectiveness.
What to do: You should take attapulgite at least 2 hours before or 2 hours after the penicillAMINE dose, penicillAMINE should be taken at least 2 hours before and not less than 6 hours after Suprep Bowel Prep (magnesium/potassium/sodium sulfates), or penicillAMINE and attapulgite should be taken as directed by your healthcare provider.
Talk to your healthcare provider if you are unsure whether your medications contain something that could potentially interact or if you have questions on how to take this or other medications you are prescribed.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:Food/Lifestyle penicillAMINE
Applies to: Depen (penicillamine)
You may experience reduced absorption of penicillAMINE in the presence of food. The effectiveness of the antibiotic may be reduced.
PenicillAMINE should be administered one hour before or two hours after meals and at least one hour apart from any other drug, food, or milk. This will make it easier for your body to absorb the medication.
Moderate:multivitamins with minerals penicillAMINE
Applies to: Depen (penicillamine)
PenicillAMINE and multivitamins with minerals should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of penicillAMINE into the bloodstream and reduce its effectiveness.
What to do: You should take multivitamins with minerals at least 2 hours before or 2 hours after the penicillAMINE dose, penicillAMINE should be taken at least 2 hours before and not less than 6 hours after Suprep Bowel Prep (magnesium/potassium/sodium sulfates), or penicillAMINE and multivitamins with minerals should be taken as directed by your healthcare provider.
Talk to your healthcare provider if you are unsure whether your medications contain something that could potentially interact or if you have questions on how to take this or other medications you are prescribed.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
9 potential interactionsApplies to: 9 conditions, including Allergies, Asthma, Fever, Myasthenia Gravis, and Gallstones.
Allergies
Moderate:Depen
The penicillAMINE in Depen has a moderate potential interaction with Allergies.
Penicillin products should be used with caution in individuals with histories of significant allergies and/or asthma.
Asthma
Moderate:Depen
The penicillAMINE in Depen has a moderate potential interaction with Asthma.
Penicillin products should be used with caution in individuals with histories of significant allergies and/or asthma.
Bone Marrow Depression/Low Blood Counts
Major:Depen
The penicillAMINE in Depen has a major potential interaction with Bone Marrow Depression/Low Blood Counts.
The use of penicillamine is contraindicated in patients with a history of penicillamine-related aplastic anemia or agranulocytosis.
Fever
Moderate:attapulgite
Attapulgite has a moderate potential interaction with Fever.
Patients with diarrhea and fever should be seen by a physician. The potential for the diarrhea to be associated with ulcerative colitis, Crohn's disease, or amebiasis is increased in these patients.
Gallstones
Moderate:Depen
The penicillAMINE in Depen has a moderate potential interaction with Gallstones.
Cases of intrahepatic cholestasis and toxic hepatitis have been reported with the use of penicillamine. Care should be taken and liver function tests are recommended every six months for the duration of therapy.
Goodpasture Syndrome
Moderate:Depen
The penicillAMINE in Depen has a moderate potential interaction with Goodpasture Syndrome.
The use of penicillamine has been associated with fatalities due to certain diseases such as Goodpasture's syndrome, and myasthenia gravis. Caution is advised in patients with these conditions.
Liver Disease
Moderate:Depen
The penicillAMINE in Depen has a moderate potential interaction with Liver Disease.
Cases of intrahepatic cholestasis and toxic hepatitis have been reported with the use of penicillamine. Care should be taken and liver function tests are recommended every six months for the duration of therapy.
Myasthenia Gravis
Moderate:Depen
The penicillAMINE in Depen has a moderate potential interaction with Myasthenia Gravis.
The use of penicillamine has been associated with fatalities due to certain diseases such as Goodpasture's syndrome, and myasthenia gravis. Caution is advised in patients with these conditions.
Renal Dysfunction
Major:Depen
The penicillAMINE in Depen has a major potential interaction with Renal Dysfunction.
Penicillamine is considerably excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. The use of penicillamine is contraindicated in patients with renal dysfunction. Proteinuria and/or hematuria may develop during therapy and may lead to nephrotic syndrome. Monitoring for proteinuria and hematuria is recommended. Caution should be taken and routine monitoring of renal function is recommended.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.