Drug Interaction Report

Progesterone may interfere with blood glucose control and reduce the effectiveness of pramlintide and other diabetic medications. Monitor your blood sugar levels closely. You may need a dose adjustment of your diabetic medications during and after treatment with progesterone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Grapefruit juice may increase the blood levels of certain medications such as progesterone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with progesterone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Pramlintide may interact with other medications if taken at the same time. Your other medications should be administered at least 1 hour before or 2 hours after your pramlintide injection. Talk with your doctor before using alcohol while you are using pramlintide. Using pramlintide together with alcohol can lead to hypoglycemia (low blood sugar). Alcohol can cause increased blood sugar due to the calories in alcoholic beverages. You may need a dose adjustment and you may need to check your blood sugar more often.