Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- aprepitant
- fosphenytoin
Interactions between your drugs
fosphenytoin aprepitant
Applies to: fosphenytoin, aprepitant
MONITOR: Theoretically, coadministration of phenytoin and aprepitant may result in decreased plasma concentrations of both drugs. The mechanism is phenytoin induction of CYP450 3A4, of which aprepitant is a substrate, and aprepitant induction of CYP450 2C9, of which phenytoin is a substrate.
MANAGEMENT: During coadministration of aprepitant and phenytoin, the possibility of a diminished therapeutic response to both drugs should be considered. Pharmacologic response should be monitored more closely whenever one or the other drug is added to or withdrawn from therapy, and the dosage(s) adjusted as necessary.
References (2)
- (2003) "Product Information. Emend (aprepitant)." Merck & Co., Inc
- (2008) "Product Information. Emend for Injection (fosaprepitant)." Merck & Co., Inc
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Zofran
Zofran (ondansetron) is used to prevent nausea and vomiting caused by surgery or cancer medicines ...
Reglan
Reglan (metoclopramide) is used to treat heartburn caused by gastric reflux. Includes Reglan side ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Zofran ODT
Zofran ODT is used for nausea/vomiting, nausea/vomiting, chemotherapy induced, nausea/vomiting ...
Emend
Emend is used to prevent nausea and vomiting caused by chemotherapy. Learn about side effects ...
Diphenidol
Diphenidol is used for meniere's disease, nausea/vomiting, nausea/vomiting, postoperative, vertigo
Palonosetron
Palonosetron is used for nausea/vomiting, nausea/vomiting, chemotherapy induced, nausea/vomiting ...
Granisetron
Granisetron is used for nausea/vomiting, nausea/vomiting, chemotherapy induced, nausea/vomiting ...
Amisulpride
Amisulpride is used for nausea/vomiting, postoperative, persistent depressive disorder, schizophrenia
Droperidol
Droperidol is used for nausea/vomiting, nausea/vomiting, postoperative
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.