Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- trimetrexate
- Zelvysia (sapropterin)
Interactions between your drugs
trimetrexate sapropterin
Applies to: trimetrexate, Zelvysia (sapropterin)
MONITOR: Drugs that affect folate metabolism may reduce the efficacy of sapropterin, which is a synthetic form of tetrahydrobiopterin (BH4). Folate antagonists can decrease tetrahydrobiopterin (BH4) levels by inhibiting the enzyme dihydropteridine reductase.
MANAGEMENT: Caution is advised if sapropterin is used in combination with folate antagonists. The potential for diminished pharmacologic effects of sapropterin should be considered.
References (1)
- (2007) "Product Information. Kuvan (sapropterin)." BioMarin Pharmaceutical Inc
Drug and food interactions
sapropterin food
Applies to: Zelvysia (sapropterin)
ADJUST DOSING INTERVAL: Food increases the gastrointestinal absorption of sapropterin.
MANAGEMENT: Sapropterin should be administered with food, preferably at the same time each day. Sapropterin tablets should be dissolved in 4 to 8 ounces (120 to 240 mL) of water or apple juice and taken within 15 minutes of dissolution.
References (4)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- (2007) "Product Information. Kuvan (sapropterin)." BioMarin Pharmaceutical Inc
- Cerner Multum, Inc. "Australian Product Information."
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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