Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- trimetrexate
- Zelvysia (sapropterin)
Interactions between your drugs
trimetrexate sapropterin
Applies to: trimetrexate, Zelvysia (sapropterin)
Trimetrexate may decrease the effects of sapropterin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
sapropterin food
Applies to: Zelvysia (sapropterin)
Food increases the absorption of sapropterin. Sapropterin should be administered with food, preferably at the same time each day. Sapropterin tablets should be dissolved in 4 to 8 ounces (120 to 240 mL) of water or apple juice and taken within 15 minutes of dissolution.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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SMZ-TMP DS
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Co-trimoxazole
Co-trimoxazole is used for bacterial infection, bacterial skin infection, bronchitis ...
Septra
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Septra DS
Septra DS is used for bacterial infection, bacterial skin infection, bronchitis, diverticulitis ...
Mepron
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Sulfatrim
Sulfatrim is used for bacterial infection, bacterial skin infection, bronchitis, diverticulitis ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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