Drug Interaction Report

Trimethoprim may increase the blood levels and side effects of PRALAtrexate. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor immediately if you develop symptoms of potentially serious side effects of PRALAtrexate such as mouth ulcers or sores; vomiting; diarrhea; rash; loss of appetite; joint pain or swelling; yellow discoloration of skin and eyes; dark urine; paleness; dizziness or fainting; unusual bruising or bleeding; infection; and flu-like symptoms (fever, chills, body aches, sore throat, muscle weakness). It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Ask your doctor before using sulfamethoxazole together with ethanol (alcohol). Contact your doctor if you experience unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, or vomiting. If you experience these side effects, you may need to avoid ethanol (alcohol) while taking sulfamethoxazole. You should check your food and medicine labels to see if these products contain ethanol (alcohol). It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.