Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Anectine (succinylcholine)
- promazine
Interactions between your drugs
promazine succinylcholine
Applies to: promazine, Anectine (succinylcholine)
MONITOR: The combination of succinylcholine and promazine may lengthen the duration of neuromuscular blockade. Prolonged apnea has been reported in one case. The proposed mechanism is promazine-induced inhibition of plasma cholinesterase.
MANAGEMENT: Patients should be monitored for prolonged neuromuscular blockade if they are given promazine after receiving succinylcholine.
References (1)
- Regan AG, Aldrete JA (1967) "Prolonged apnea after administration of promazine hydrochloride following succinylcholine infusion." Anesth Analg, 46, p. 315-8
Drug and food interactions
promazine food
Applies to: promazine
GENERALLY AVOID: Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment. Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines. The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
MANAGEMENT: Patients should be advised to avoid alcohol during phenothiazine therapy.
References (2)
- Lutz EG (1976) "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA, 236, p. 2422-3
- Freed E (1981) "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust, 2, p. 44-5
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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