Drug Interaction Report

Rofecoxib may increase the blood levels of rOPINIRole. This may increase the risk and/or severity of side effects such as nausea, vomiting, weakness, drowsiness, fainting, agitation, and confusion. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Alcohol can increase the nervous system side effects of rOPINIRole such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with rOPINIRole. Do not use more than the recommended dose of rOPINIRole, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.