Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- rifabutin
- Viramune XR (nevirapine)
Interactions between your drugs
rifabutin nevirapine
Applies to: rifabutin, Viramune XR (nevirapine)
Rifabutin may modestly reduce plasma concentrations of nevirapine (by 16%). The mechanism is induction of CYP450 3A4 hepatic metabolism. Data are insufficient to determine the clinical significance or whether dosage adjustments are necessary. The manufacturer recommends that these drugs should be used in combination with caution and only if clearly indicated. Patients should be monitored for altered therapeutic effect.
References (4)
- (2001) "Product Information. Viramune (nevirapine)." Boehringer-Ingelheim
- Burman WJ, Jones BE (2001) "Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy." Am J Respir Crit Care Med, 164, p. 7-12
- (2000) "Notice to readers: updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibiotrs." MMWR Morb Mortal Wkly Rep, 49, p. 185-9
- Back D, Gibbons S, Khoo S (2003) "Pharmacokinetic drug interactions with nevirapine." J Acquir Immune Defic Syndr, 34 Suppl 1, S8-14
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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