Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- pentamidine
- Videx EC (didanosine)
Interactions between your drugs
pentamidine didanosine
Applies to: pentamidine, Videx EC (didanosine)
GENERALLY AVOID: Coadministration of intravenous pentamidine with didanosine or zalcitabine may increase the risk of pancreatitis. These drugs have individually been associated with pancreatitis and additive toxicity may occur during concomitant use. Fatalities have been reported.
MANAGEMENT: The manufacturer recommends that the antiretroviral drugs should be interrupted, if clinically feasible, when treatment with intravenous pentamidine is initiated. If concomitant use cannot be avoided, patients should be closely monitored for clinical and laboratory signs of pancreatitis.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
Drug and food interactions
didanosine food
Applies to: Videx EC (didanosine)
ADJUST DOSING INTERVAL: Didanosine bioavailability is decreased when administered with food. Loss of efficacy may result.
MANAGEMENT: Didanosine should be administered in the fasting state, at least 30 minutes before or more than 2 hours after eating.
References (1)
- (2002) "Product Information. Videx (didanosine)." Bristol-Myers Squibb
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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