Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- pantoprazole
- vandetanib
Interactions between your drugs
pantoprazole vandetanib
Applies to: pantoprazole, vandetanib
The use of vandetanib with proton pump inhibitors may theoretically reduce its gastrointestinal absorption. Vandetanib exhibits pH-dependent solubility, with increased solubility at lower pH. The clinical significance is unknown. In healthy subjects, no clinically significant changes in the Cmax and AUC of vandetanib occurred, after coadministration of a single dose of vandetanib with five daily doses of omeprazole, or after coadministration of a single dose of vandetanib and two doses of ranitidine 12 hours apart. Dose adjustments are not required when vandetanib is administered with omeprazole or ranitidine.
References (4)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
- Cerner Multum, Inc. "Australian Product Information."
- (2011) "Product Information. Vandetanib (vandetanib)." Astra-Zeneca Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Prilosec
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Flagyl
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Carafate
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Amoxil
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Pepto-Bismol
Pepto-Bismol is antacid used to treat heart burn, indigestion, diarrhea, gas or an upset stomach ...
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Further information
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