Drug Interaction Report

Amiodarone may increase the blood levels and effects of seladelpar. This can increase the risk and/or severity of side effects such as changes in your liver tests, headache, stomach pain or swelling (distension), nausea, and/or dizziness. Your healthcare provider may already be aware of the risks, but has determined that this is the best course of treatment for you and is monitoring you closely for any potential complications. Speak with your healthcare provider right away if you develop any of the following signs or symptoms during treatment with seladelpar as they may indicate worsening liver problems: swelling of your stomach-area (abdomen) from a build-up of fluid, yellowing of your skin or the whites of your eyes, pain on the right side of your stomach, coughing or vomiting up blood or blood clots, red or black stools that look like tar, and/or mental changes like confusion, slurred speech, or changes in personality. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Amiodarone may be taken with or without food but should be taken at the same way each time. You should avoid consuming grapefruits and grapefruit juice while taking amiodarone. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Grapefruit can raise the levels of amiodarone in your body and lead to dangerous side effects. This can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea.