Skip to main content

Seladelpar

Pronunciation: sell-a-dell-pah
Generic name: seladelpar
Brand name: Livdelzi
Dosage form: oral capsule (10 mg)
Drug class: Miscellaneous metabolic agents

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 4, 2025.

What is Seladelpar? PBC Treatment

Seladelpar is used to treat primary biliary cholangitis (PBC) in adults. It is an oral capsule taken once a day in combination with ursodeoxycholic acid (UDCA) in adults who have not responded well to UDCA, or used alone in those unable to tolerate UDCA.

Seladelpar is not used in people with advanced liver disease (decompensated cirrhosis).

Key Facts About Seladelpar (Livdelzi)

How does Seladelpar Work? 

Mechanism of Action

Seladelpar belongs to the drug class called peroxisome proliferator-activated receptor (PPAR)-delta agonists and works through multiple pathways:

Clinical benefit: By reducing bile acid production, seladelpar helps counteract liver damage caused by bile acid buildup in PBC patients, although it is unknown if it improves survival or prevents liver decompensation.

Clinical Trial Results

Approval of seladelpar was based on the results of the Phase 3 RESPONSE trial (NCT04620733), which reported:

Seladelpar Side Effects

Common side effects

The most common side effects of seladelpar are:

Serious side effects and warnings

Bone Fractures

Seladelpar may increase your risk of bone fractures.

Liver Function Changes

Increased liver enzymes in the blood have occurred when taking more seladelpar than prescribed. Your healthcare provider will do tests to check your liver before you start and during treatment with seladelpar. Tell your healthcare provider right away if you have any of the following signs or symptoms of worsening liver problems during treatment with seladelpar:

It is not known if seladelpar is safe and effective in children.

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of seladelpar. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking

Absolute Contraindications

Do not use seladelpar in:

Signs of advanced liver disease include:

Tell Your Healthcare Provider if You Have:

Pregnancy and Breastfeeding Considerations

Pregnancy: It is not known if seladelpar will harm an unborn baby. If you become pregnant while taking seladelpar, tell your healthcare provider right away.

Pregnancy Safety Study. Talk to your healthcare provider about providing information about the Livdelzi (seladelpar) pregnancy safety study. The purpose of this pregnancy safety study is to capture information about your health and your baby’s health. You or your healthcare provider can report your pregnancy by calling 1-800-445-3235.

Breastfeeding: It is not known if seladelpar passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby if you take seladelpar.

How to Take Seladelpar: Dosage and Administration

Standard Seladelpar Dosage

Important Timing with Other Medications

Bile acid-binding resins (cholestyramine, colestipol):

What happens if I overdose

If you take too much seladelpar, call your healthcare provider or get emergency medical help right away.

What other drugs will affect seladelpar?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Seladelpar can affect the way certain medicines work. Certain other medicines may affect the way this medicine works.

Major Drug Interactions to Avoid

Strong CYP2C9 Inhibitors (avoid combination):

OAT3 Inhibitors (avoid or monitor closely):

Monitor Closely With These Medications

Dual CYP2C9/CYP3A4 Inhibitors:

BCRP Inhibitors:

CYP2C9 Poor Metabolizers:

Bile Acid Binding Resins

Seladelpar should be taken at least 4 hours before or 4 hours after you take medicines to help lower your cholesterol, called bile acid-binding resins (examples include cholestyramine or colestipol). If this is not possible, space the time between taking seladelpar and your bile acid-binding resin as far apart as possible.

This is not a complete list of interactions. See the Livdelzi (seladelpar) Package Insert for a full list.

Does Seladelpar interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Storage

Store capsules at room temperature between 68°F to 77°F (20°C to 25°C).

Keep out of the reach of children.

Ingredients

Seladelpar is only available under the brand name Livdelzi. There is no generic.

Active ingredient: seladelpar lysine

Inactive ingredients (Livdelzi): butylated hydroxytoluene, colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, mannitol, microcrystalline cellulose, and hard gelatin shells.

Capsule shells contain gelatin, titanium dioxide, black iron oxide, yellow iron oxide, red iron oxide, and the colorant FD&C Blue #2.

Seladelpar is available as a 10 mg capsule.

Manufacturer

Seladelpar is manufactured by Gilead Sciences, Inc., under the brand Livdelzi. Gilead Sciences' headquarters are in Foster City, California. 

Frequently Asked Questions About Seladelpar

How effective is seladelpar for PBC?

In clinical trials, 62% of patients achieved composite biochemical response compared to 20% on placebo, with 25% achieving normalized ALP levels.

Can seladelpar be used alone without UDCA?

Yes, seladelpar can be used as monotherapy in patients who cannot tolerate UDCA.

What's the difference between seladelpar and Ocaliva?

Seladelpar is a PPAR-delta agonist that may reduce itching, while Ocaliva is an FXR agonist that may worsen itching but has longer clinical experience.

How much does seladelpar cost?

Without insurance, seladelpar costs approximately $3,000-5,000+ per month. Patient assistance programs may be available.

Is seladelpar better than UDCA?

Seladelpar isn't meant to replace UDCA but to work with it or substitute when UDCA isn't effective or tolerated.

What are the long-term effects of seladelpar?

Long-term data is limited due to its recent approval. The main concern is increased bone fracture risk requiring monitoring.

Can I stop taking seladelpar if I feel better?

No, PBC is a chronic condition requiring ongoing treatment. Stopping medication may lead to disease progression.

Will seladelpar cure my PBC?

Seladelpar doesn't cure PBC but helps control the disease and may slow progression. Long-term outcomes are still being studied.

More about seladelpar

Patient resources

Other brands

Livdelzi

Professional resources

Other brands

Livdelzi

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.