Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Posicor (mibefradil)
- vorapaxar
Interactions between your drugs
mibefradil vorapaxar
Applies to: Posicor (mibefradil), vorapaxar
GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of vorapaxar, which is a substrate of the isoenzyme. When vorapaxar was coadministered with ketoconazole 400 mg, mean vorapaxar peak plasma concentration (Cmax) and systemic exposure (AUC) increased by nearly 2-fold.
MANAGEMENT: Concomitant use of vorapaxar with potent CYP450 3A4 inhibitors should generally be avoided. Some authorities recommend avoiding concomitant use of vorapaxar during and for 2 weeks after treatment with itraconazole.
References (3)
- (2002) "Product Information. Sporanox (itraconazole)." Janssen Pharmaceuticals
- Cerner Multum, Inc. "Australian Product Information."
- (2014) "Product Information. Zontivity (vorapaxar)." Merck & Co., Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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