Drug Interaction Report

Amikacin can occasionally cause muscle paralysis, and using it with magnesium sulfate may increase that risk. Although the effect is often self-limiting and not associated with serious injury, respiratory arrest and death can occur when paralysis involves the lung muscles. This is most likely to occur if you are receiving high dosages of either medication or if you have kidney disease. You should be closely monitored by a doctor during treatment. Let your doctor know if you experience muscle weakness and/or breathing difficulties. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.