Drug Interaction Report
4 potential interactions and/or warnings found for the following 2 drugs:
- Aspercreme Maximum Strength Lidocaine Creme (lidocaine topical)
- cimetidine
Interactions between your drugs
cimetidine lidocaine topical
Applies to: cimetidine, Aspercreme Maximum Strength Lidocaine Creme (lidocaine topical)
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with cimetidine may increase the plasma concentration of topical lidocaine formulations. In a study of healthy volunteers, cimetidine increased the systemic exposure (AUC) of a 10% topical lidocaine spray applied to the pharynx by 1.5-fold. The proposed mechanism for this interaction is cimetidine-mediated inhibition of CYP450 1A2 and 3A4 which are involved in the metabolism of lidocaine. The degree of systemic absorption of topical lidocaine may be dependent on the duration of application and the applied surface area.
MANAGEMENT: The potential for an interaction should be considered during concomitant use of cimetidine and topical lidocaine formulations. If coadministration is required, patients should be monitored for lidocaine-related adverse effects or toxicities including drowsiness, mental status change, or tremor.
Drug and food/lifestyle interactions
cimetidine food/lifestyle
Applies to: cimetidine
Information for this minor interaction is available on the professional version.
cimetidine food/lifestyle
Applies to: cimetidine
Information for this minor interaction is available on the professional version.
cimetidine food/lifestyle
Applies to: cimetidine
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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