Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- lansoprazole
- Theocon Elixir (guaifenesin / oxtriphylline)
Interactions between your drugs
oxtriphylline lansoprazole
Applies to: Theocon Elixir (guaifenesin / oxtriphylline), lansoprazole
Lansoprazole may cause a minor decrease in the area under the plasma concentration-time curve of theophylline and related drugs. This effect appears to be small (approximately a 13% decrease in one study) and may be related either to a reduction in absorption or to enhanced clearance caused by induction of hepatic enzymes by lansoprazole. Dosage adjustment is not believed to be necessary. However, close observation for evidence of altered methylxanthine effect is recommended.
References (4)
- (2001) "Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc
- Granneman GR, Karol MD, Locke CS (1995) "Pharmacokinetic interaction between lansoprazole and theophylline." Ther Drug Monit, 17, p. 460-4
- Kokufu T, Ihara N, Sugioka N, Koyama H, Ohta T, Mori S, Nakajima K (1995) "Effects of lansoprazole on pharmacokinetics and metabolism of theophylline." Eur J Clin Pharmacol, 48, p. 391-5
- Ko JW, Jang IJ, Shin JG, Nam SK, Shin SG, Flockhart DA (1999) "Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers." Clin Pharmacol Ther, 65, p. 606-14
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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