Drug Interaction Report

Using pitolisant together with ketoprofen may increase the risk of side effects in the gastrointestinal tract such as upset stomach, bloating, abdominal pain or discomfort, and stomach inflammation. It is not known whether pitolisant will increase the risk of more serious gastrointestinal side effects such as bleeding and ulceration that are often associated with the use of ketoprofen and similar medications. You should take these medications with food to lessen the risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Your doctor may also be able to recommend medications to help protect the stomach and intestine if you are at high risk for developing serious gastrointestinal complications. You should seek immediate medical attention if you experience severe gastrointestinal effects or have signs and symptoms of gastrointestinal bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Ask your doctor before using ketoprofen together with ethanol (alcohol). Do not drink alcohol while taking ketoprofen. Alcohol can increase your risk of stomach bleeding caused by ketoprofen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.