Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Absorica LD (isotretinoin)
- thiotepa
Interactions between your drugs
thiotepa ISOtretinoin
Applies to: thiotepa, Absorica LD (isotretinoin)
Coadministration of thiotepa may increase plasma concentrations of drugs that are primarily metabolized by CYP450 2B6. Thiotepa has been shown to be a weak inhibitor of CYP450 2B6 in vitro, although drug interactions studies are not available, and the clinical significance is unknown. Product labeling for the specific CYP450 2B6 substrate should be consulted for additional recommendations and monitoring for increased adverse effects when used concomitantly with thiotepa may be warranted.
References (4)
- (2023) "Product Information. Thiotepa (thiotepa)." Meitheal Pharmaceuticals Inc.
- (2023) "Product Information. Tepadina (thiotepa)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 3
- (2022) "Product Information. Thiotepa (thiotepa)." MSN Laboratories Europe Ltd
- (2021) "Product Information. Tepadina (thiotepa)." Adienne SA
Drug and food interactions
ISOtretinoin food
Applies to: Absorica LD (isotretinoin)
GENERALLY AVOID: The combined use of ethanol and isotretinoin may result in a disulfiram-like reaction. The mechanism has not been established.
MANAGEMENT: Alcohol consumption should be avoided during isotretinoin therapy.
References (1)
- (2001) "Product Information. Accutane (isotretinoin)." Roche Laboratories
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Clindamycin topical
Clindamycin topical is used for acne, bacterial vaginosis, perioral dermatitis
Vibramycin
Vibramycin is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Taltz
Taltz (ixekizumab) is used to treat plaque psoriasis, psoriatic arthritis, and ankylosing ...
Tazorac
Tazorac cream and gel is used to treat acne and plaque psoriasis. Includes Tazorac side effects ...
Soolantra
Soolantra (ivermectin) is used to treat rosacea. Includes Soolantra side effects, interactions and ...
Minocycline topical
Minocycline topical is used for acne, periodontitis, rosacea
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.