Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- altretamine
- Aminoxin (pyridoxine)
Interactions between your drugs
pyridoxine altretamine
Applies to: Aminoxin (pyridoxine), altretamine
GENERALLY AVOID: Data from a randomized trial of altretamine and cisplatin in ovarian cancer indicated that pyridoxine significantly reduced neurotoxicity but also adversely affected response duration. The mechanism of interaction has not been established.
MANAGEMENT: Until further data are available, it may be advisable to avoid using altretamine with pyridoxine.
References (2)
- (2022) "Product Information. Hexalen (altretamine)." US Bioscience
- Wiernik PH, Yeap B, Vogl SE, et al. (1992) "Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology Group." Cancer Invest, 10, p. 1-9
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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