Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- heparin
- Staphcillin (methicillin)
Interactions between your drugs
methicillin heparin
Applies to: Staphcillin (methicillin), heparin
Case reports have suggested that intravenous penicillins may intensify the effect of heparin by inhibition of platelet aggregation; however, causality has not been clearly determined. Patients should be monitored for bleeding problems. Protamine sulfate may be useful for clinically important bleeding.
References (3)
- Wisloff F, Larsen JP, Dahle A, Lie M, Godal HC (1983) "Effect of prophylactic high-dose treatment with ampicillin and cloxacillin on bleeding time and bleeding in patients undergoing elective vascular surgery." Scand J Haematol, 31, p. 97-101
- Brown CH, Natelson EA, Bradshaw W, Williams TW, Alfrey CP (1974) "The hemostatic defect produced by carbenicillin." N Engl J Med, 291, p. 265-70
- Tabernero JM, Corbacho RL, Sanchez S, et al. (1979) "Effects of carbenicillin on blood coagulation: a study in patients with chronic renal failure." Clin Nephrol, 11, p. 31-4
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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