Drug Interaction Report

Consumer information for this interaction is not currently available.

MONITOR: Adenosine has induced torsade de pointes arrhythmia in patients with preexisting long QT syndrome. Theoretically, coadministration of adenosine with agents that can prolong the QT interval may increase that risk as well. The mechanism has not been established, but may involve the depressant effect of adenosine on the sinoatrial and atrioventricular nodes. Rare cases of severe bradycardia have been reported during treatment with adenosine, which could favor the occurrence of torsade de pointes, especially in patients with prolonged QT intervals. Interestingly, no case of torsade de pointes has been reported when adenosine is given by continuous infusion.

MANAGEMENT: Adenosine should be used with caution in patients receiving drugs that may prolong the QT interval. Adenosine should be discontinued immediately if severe bradycardia occurs.

Adenosine is used for heart imaging in the hospital or clinic setting. Caffeine should be avoided for 12 to 24 hours before adenosine administration. Avoid drinks, foods, or diet pills that contain caffeine, such as coffee, tea, cola, and chocolate. Taking a stimulant together with adenosine can increase your risk of unpleasant side effects.

Ask your doctor before using adenosine together with caffeine. Using these medications together can decrease the effects of adenosine. It is recommended that caffeine including caffeine be avoided for 12 to 24 hours before adenosine administration. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Information for this minor interaction is available on the professional version.