Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- Estragyn 5 (estrone)
- pretomanid
Interactions between your drugs
estrone pretomanid
Applies to: Estragyn 5 (estrone), pretomanid
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with pretomanid may significantly increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of organic anion transporter 3 (OAT3). The proposed mechanism, based on in vitro data, is decreased clearance due to pretomanid-mediated inhibition of OAT3. No clinical interaction studies have been conducted in humans with OAT3 substrates.
MANAGEMENT: Caution is advised if pretomanid is used concomitantly with drugs that are substrates of OAT3, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring of the OAT3 substrate drug should be considered whenever pretomanid is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.
Drug and food interactions
pretomanid food
Applies to: pretomanid
Food can enhance the levels of pretomanid in your body. Pretomanid should be taken just after eating food. Do not take it on an empty stomach. This will make it easier for your body to absorb the medication. Swallow tablets whole. Do not crush, chew, or break the tablets.
estrone food
Applies to: Estragyn 5 (estrone)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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